MEC3_CAEBR
ID MEC3_CAEBR Reviewed; 318 AA.
AC P34764; A8X6F8; Q61MQ2;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Mechanosensory protein 3;
GN Name=mec-3; ORFNames=CBG08386;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-296.
RX PubMed=1361171; DOI=10.1002/j.1460-2075.1992.tb05604.x;
RA Xue D., Finney M., Ruvkun G., Chalfie M.;
RT "Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and
RT MEC-3.";
RL EMBO J. 11:4969-4979(1992).
CC -!- FUNCTION: Specifies differentiation of the set of six touch receptor
CC neurons. Binds cooperatively as a heterodimer with unc-86 to sites in
CC the mec-3 gene promoter.
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; HE601100; CAP28219.3; -; Genomic_DNA.
DR EMBL; L02878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; S29399; S29399.
DR RefSeq; XP_002634577.1; XM_002634531.1.
DR AlphaFoldDB; P34764; -.
DR SMR; P34764; -.
DR STRING; 6238.CBG08386; -.
DR EnsemblMetazoa; CBG08386a.1; CBG08386a.1; WBGene00030186.
DR GeneID; 8576570; -.
DR KEGG; cbr:CBG_08386; -.
DR CTD; 8576570; -.
DR WormBase; CBG08386a; CBP02049; WBGene00030186; Cbr-mec-3.
DR eggNOG; KOG0490; Eukaryota.
DR HOGENOM; CLU_027802_2_1_1; -.
DR InParanoid; P34764; -.
DR OMA; SYHENCV; -.
DR OrthoDB; 1014909at2759; -.
DR Proteomes; UP000008549; Chromosome IV.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 4: Predicted;
KW Developmental protein; DNA-binding; Homeobox; LIM domain; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Zinc.
FT CHAIN 1..318
FT /note="Mechanosensory protein 3"
FT /id="PRO_0000075839"
FT DOMAIN 27..86
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 87..152
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 214..273
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT CONFLICT 40
FT /note="F -> Y (in Ref. 2; L02878)"
FT /evidence="ECO:0000305"
FT CONFLICT 83..87
FT /note="DYSAH -> TTVLN (in Ref. 2; L02878)"
FT /evidence="ECO:0000305"
FT CONFLICT 98
FT /note="P -> A (in Ref. 2; L02878)"
FT /evidence="ECO:0000305"
FT CONFLICT 101
FT /note="M -> N (in Ref. 2; L02878)"
FT /evidence="ECO:0000305"
FT CONFLICT 161..166
FT /note="DVPSCS -> AFLVP (in Ref. 2; L02878)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="K -> Q (in Ref. 2; L02878)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="F -> L (in Ref. 2; L02878)"
FT /evidence="ECO:0000305"
FT CONFLICT 217
FT /note="P -> L (in Ref. 2; L02878)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="R -> K (in Ref. 2; L02878)"
FT /evidence="ECO:0000305"
FT CONFLICT 230
FT /note="N -> Q (in Ref. 2; L02878)"
FT /evidence="ECO:0000305"
FT CONFLICT 243
FT /note="A -> R (in Ref. 2; L02878)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 318 AA; 36611 MW; 4E9232039CC5A8C5 CRC64;
MEVLESKPLS AISMVIDAIG VEHDSQNKCY CCNEQIFDRF ICRMDNRSYH ENCVKCAICE
SPLAEKCFWK NGTIYCSQHY YKDYSAHRCA GCKKGVSPTD MVYKLKAGLV FHVECHCCTL
CGRHLSPGEQ ILVDDTMMTV SCMSHYPLPM DDPCPPVGPS DVPSCSSDAS AVAPYPMDES
FPFQIKKEVD AYGYNFEHYS FSDFCDDDSR MLKRRGPRTT IRQNQLDVLN EMFSNTPKPS
KHARAKLALE TGLSMRVIQV WFQNRRSKER RLKHLCNYLR HYEQRGLIPP PIHFRNEEMD
GTDFNSFCGN FEEEDDED
