ID   MEC3_CAERE              Reviewed;         320 AA.
AC   P34765;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Mechanosensory protein 3;
GN   Name=mec-3;
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=31234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1684166; DOI=10.1101/gad.5.12a.2199;
RA   Way J.C., Wang L., Run J.Q., Wang A.;
RT   "The mec-3 gene contains cis-acting elements mediating positive and
RT   negative regulation in cells produced by asymmetric cell division in
RT   Caenorhabditis elegans.";
RL   Genes Dev. 5:2199-2211(1991).
CC   -!- FUNCTION: Specifies differentiation of the set of six touch receptor
CC       neurons. Binds cooperatively as a heterodimer with unc-86 to sites in
CC       the mec-3 gene promoter.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; X63956; CAA45377.1; -; Genomic_DNA.
DR   PIR; A39479; A39479.
DR   AlphaFoldDB; P34765; -.
DR   SMR; P34765; -.
DR   STRING; 31234.CRE10916; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   HOGENOM; CLU_027802_2_1_1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00132; LIM; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   4: Predicted;
KW   Developmental protein; DNA-binding; Homeobox; LIM domain; Metal-binding;
KW   Nucleus; Repeat; Zinc.
FT   CHAIN           1..320
FT                   /note="Mechanosensory protein 3"
FT                   /id="PRO_0000075841"
FT   DOMAIN          29..79
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          89..145
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DNA_BIND        216..275
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   320 AA;  36850 MW;  AF98BD31C2B2FDB6 CRC64;
     MELLESKPLS AISMVIDSIG VDHDSQNKCN CCNEQIYDRF IYRMDNHSYH ENCVKCTICE
     SPLAEKCFWK NGRIYCSQHY YKDHSSHRCA GCKKGVSPTD MVYKLKAGLV FHVECHCCSL
     CGRHLSPGEQ ILVDDTMMTV SCMTHYPPQM DDSCGPPAGT SEVPSCSSDS AIAPYPMDEG
     FPSAFQVKKE VDAYGYNFEH YSFSDFCDDD SRMLKRRGPR TTIKQNQLDV LNEMFSNTPK
     PSKHARAKKA LETGLSMRVI QVWFQNRRSK ERRLKHLCNY LRHYEQRGLI PPPIHFRNEE
     MDTTDFNSFC GNFEEEDDED