ID   MECA1_BACAN             Reviewed;         227 AA.
AC   Q81TR3; Q6I1Z7; Q6KVT6;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 2.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Adapter protein MecA 1;
GN   Name=mecA1; Synonyms=mecA; OrderedLocusNames=BA_1203, GBAA_1203, BAS1111;
OS   Bacillus anthracis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1392;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ames / isolate Porton;
RX   PubMed=12721629; DOI=10.1038/nature01586;
RA   Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA   Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA   Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA   Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA   DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA   Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA   Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA   Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA   White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA   Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT   "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT   related bacteria.";
RL   Nature 423:81-86(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ames ancestor;
RX   PubMed=18952800; DOI=10.1128/jb.01347-08;
RA   Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA   Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT   "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL   J. Bacteriol. 191:445-446(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sterne;
RA   Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA   Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA   Richardson P., Rubin E., Tice H.;
RT   "Complete genome sequence of Bacillus anthracis Sterne.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. Acts negatively in the development of competence by
CC       binding ComK and recruiting it to the ClpCP protease. When
CC       overexpressed, inhibits sporulation. Also involved in Spx degradation
CC       by ClpC (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- DOMAIN: The N-terminal domain has binding sites for ComK and probably
CC       for unfolded/aggregated proteins; the C-terminal domain interacts with
CC       ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT30290.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016879; AAP25164.2; -; Genomic_DNA.
DR   EMBL; AE017334; AAT30290.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017225; AAT53434.1; -; Genomic_DNA.
DR   RefSeq; NP_843678.2; NC_003997.3.
DR   RefSeq; WP_000350710.1; NZ_WXXJ01000044.1.
DR   RefSeq; YP_027383.1; NC_005945.1.
DR   AlphaFoldDB; Q81TR3; -.
DR   SMR; Q81TR3; -.
DR   STRING; 261594.GBAA_1203; -.
DR   DNASU; 1089261; -.
DR   EnsemblBacteria; AAP25164; AAP25164; BA_1203.
DR   EnsemblBacteria; AAT30290; AAT30290; GBAA_1203.
DR   GeneID; 64200122; -.
DR   KEGG; ban:BA_1203; -.
DR   KEGG; bar:GBAA_1203; -.
DR   KEGG; bat:BAS1111; -.
DR   PATRIC; fig|198094.11.peg.1180; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_2_1_9; -.
DR   OMA; EFFYTVM; -.
DR   Proteomes; UP000000427; Chromosome.
DR   Proteomes; UP000000594; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   GO; GO:0045808; P:negative regulation of establishment of competence for transformation; IEA:UniProtKB-UniRule.
DR   GO; GO:0042174; P:negative regulation of sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
KW   Competence; Reference proteome; Sporulation.
FT   CHAIN           1..227
FT                   /note="Adapter protein MecA 1"
FT                   /id="PRO_0000212260"
SQ   SEQUENCE   227 AA;  26966 MW;  38F0F0587F3C15AD CRC64;
     MDIERINDHT MKFFITYIDI EDRGFNREEI WYDRERSEEL FWEMMDEARD HDDFFIDGPL
     WIQVQAVDKG IEVLVTKAEL SKDGQKLELP IGVDKIIDIP LDEGIESLFQ QELVEEVEEQ
     AGTNFNEDGT FGFLIKFNDF EDVISLSHRL IFEDIKDELY SFEDRYYVYV EFDEVLHDEE
     EIDRILSIVL EYGEESTLTI HRVSEYGKQI VKEHALETIR NNFPAKT