MECA_ALKPO
ID MECA_ALKPO Reviewed; 217 AA.
AC O66042; D3FV22;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=BpOF4_01905;
OS Alkalihalophilus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4)
OS (Bacillus pseudofirmus).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalophilus.
OX NCBI_TaxID=398511;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9443601; DOI=10.1016/s0005-2760(97)00086-6;
RA Guo D., Tropp B.E.;
RT "Cloning of the Bacillus firmus OF4 cls gene and characterization of its
RT gene product.";
RL Biochim. Biophys. Acta 1389:34-42(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2126 / JCM 17055 / OF4;
RX PubMed=21951522; DOI=10.1111/j.1462-2920.2011.02591.x;
RA Janto B., Ahmed A., Ito M., Liu J., Hicks D.B., Pagni S., Fackelmayer O.J.,
RA Smith T.A., Earl J., Elbourne L.D., Hassan K., Paulsen I.T., Kolsto A.B.,
RA Tourasse N.J., Ehrlich G.D., Boissy R., Ivey D.M., Li G., Xue Y., Ma Y.,
RA Hu F.Z., Krulwich T.A.;
RT "Genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that
RT support the ability to grow in an external pH range from 7.5 to 11.4.";
RL Environ. Microbiol. 13:3289-3309(2011).
CC -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC aggregated proteins to the ClpC protease or to other proteins involved
CC in proteolysis. Acts negatively in the development of competence by
CC binding ComK and recruiting it to the ClpCP protease. When
CC overexpressed, inhibits sporulation. Also involved in Spx degradation
CC by ClpC. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- DOMAIN: The N-terminal domain has binding sites for ComK and probably
CC for unfolded/aggregated proteins; the C-terminal domain interacts with
CC ClpC.
CC -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC Rule:MF_01124}.
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DR EMBL; U88888; AAC05443.1; -; Genomic_DNA.
DR EMBL; CP001878; ADC48448.1; -; Genomic_DNA.
DR RefSeq; WP_012959726.1; NC_013791.2.
DR AlphaFoldDB; O66042; -.
DR SMR; O66042; -.
DR STRING; 398511.BpOF4_01905; -.
DR EnsemblBacteria; ADC48448; ADC48448; BpOF4_01905.
DR KEGG; bpf:BpOF4_01905; -.
DR eggNOG; COG4862; Bacteria.
DR HOGENOM; CLU_071496_2_1_9; -.
DR OMA; EFFYTVM; -.
DR OrthoDB; 1678325at2; -.
DR Proteomes; UP000001544; Chromosome.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR GO; GO:0045808; P:negative regulation of establishment of competence for transformation; IEA:UniProtKB-UniRule.
DR GO; GO:0042174; P:negative regulation of sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.1950; -; 1.
DR HAMAP; MF_01124; MecA; 1.
DR InterPro; IPR038471; MecA_C_sf.
DR InterPro; IPR008681; Neg-reg_MecA.
DR PANTHER; PTHR39161; PTHR39161; 1.
DR Pfam; PF05389; MecA; 1.
DR PIRSF; PIRSF029008; MecA; 1.
PE 3: Inferred from homology;
KW Competence; Reference proteome; Sporulation.
FT CHAIN 1..217
FT /note="Adapter protein MecA"
FT /id="PRO_0000212266"
SQ SEQUENCE 217 AA; 25758 MW; CA26A703A2C37949 CRC64;
MDIERVNDTT IKFFITYKDI EDRGFDRDEI WYNRERGEEL FFEMMNEAND RDEFELDGPL
WIQVHALDKG LEIVVTRGQV SDGNVKLEIP VSQDKENTDE NIVDLMTGHS SEDDEGIDTD
QLEIVIGFND FEDIISLSHN FFIDDLENEL YHFEGRYYLH VLFNDDQYNE DEQDDMLSQM
LEYGYETDLS IHRMQEYGKE IIGEYALKHL RGHFPQN
