ID   MECA_ENTFA              Reviewed;         220 AA.
AC   Q830U4;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=EF_2677;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA   DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA   Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA   Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; AE016830; AAO82382.1; -; Genomic_DNA.
DR   RefSeq; NP_816312.1; NC_004668.1.
DR   RefSeq; WP_002356478.1; NZ_KE136528.1.
DR   AlphaFoldDB; Q830U4; -.
DR   SMR; Q830U4; -.
DR   STRING; 226185.EF_2677; -.
DR   EnsemblBacteria; AAO82382; AAO82382; EF_2677.
DR   GeneID; 60894671; -.
DR   KEGG; efa:EF2677; -.
DR   PATRIC; fig|226185.45.peg.885; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_2_0_9; -.
DR   OMA; EFFYTVM; -.
DR   Proteomes; UP000001415; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..220
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_0000212269"
SQ   SEQUENCE   220 AA;  25345 MW;  40AF1044BC897BD3 CRC64;
     MEMEHINENT IRVLIGNEDL ADRGITFLDL LGNHKDVENF FYSILEEVDV EDEFQGSEAV
     TFQVLPKNDG LELFISKNVA MDDLSSLEGL SEVNADVSEL IRKQIEADKA AADELDEMEA
     TDETNRNVIF ELDNFEAMIQ LSKEVFMQSV LTNLYTYNDR YYLQVLFLTD ELEKTNVDNE
     IAQILEFAHK TTVTQDTLVE YGTCIMERSA LELTRYYFND