MECA_EXISA
ID MECA_EXISA Reviewed; 218 AA.
AC C4L574;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=EAT1b_2745;
OS Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b).
OC Bacteria; Firmicutes; Bacilli; Bacillales;
OC Bacillales Family XII. Incertae Sedis; Exiguobacterium;
OC unclassified Exiguobacterium.
OX NCBI_TaxID=360911;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1283 / AT1b;
RX PubMed=21460088; DOI=10.1128/jb.00303-11;
RA Vishnivetskaya T.A., Lucas S., Copeland A., Lapidus A., Glavina del Rio T.,
RA Dalin E., Tice H., Bruce D.C., Goodwin L.A., Pitluck S., Saunders E.,
RA Brettin T., Detter C., Han C., Larimer F., Land M.L., Hauser L.J.,
RA Kyrpides N.C., Ovchinnikova G., Kathariou S., Ramaley R.F., Rodrigues D.F.,
RA Hendrix C., Richardson P., Tiedje J.M.;
RT "Complete genome sequence of the Thermophilic Bacterium Exiguobacterium sp.
RT AT1b.";
RL J. Bacteriol. 193:2880-2881(2011).
CC -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC aggregated proteins to the ClpC protease or to other proteins involved
CC in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC proteins; the C-terminal domain interacts with ClpC.
CC -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC Rule:MF_01124}.
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DR EMBL; CP001615; ACQ71659.1; -; Genomic_DNA.
DR RefSeq; WP_015881218.1; NC_012673.1.
DR AlphaFoldDB; C4L574; -.
DR SMR; C4L574; -.
DR STRING; 360911.EAT1b_2745; -.
DR EnsemblBacteria; ACQ71659; ACQ71659; EAT1b_2745.
DR KEGG; eat:EAT1b_2745; -.
DR eggNOG; COG4862; Bacteria.
DR HOGENOM; CLU_071496_2_1_9; -.
DR OMA; EFFYTVM; -.
DR OrthoDB; 1678325at2; -.
DR Proteomes; UP000000716; Chromosome.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.1950; -; 1.
DR HAMAP; MF_01124; MecA; 1.
DR InterPro; IPR038471; MecA_C_sf.
DR InterPro; IPR008681; Neg-reg_MecA.
DR PANTHER; PTHR39161; PTHR39161; 1.
DR Pfam; PF05389; MecA; 1.
DR PIRSF; PIRSF029008; MecA; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..218
FT /note="Adapter protein MecA"
FT /id="PRO_1000213624"
SQ SEQUENCE 218 AA; 25674 MW; EDDF0743CE0FE0B2 CRC64;
MKIERINDNT VKFFITYVDI EKRGFARDEI WYNRERGEQL FWQMMDEAHE REDISFDGPL
WIQVQAFEKG LEVTVTIAKN VMDTEDDSEL GSLLRSAIDE ARDQQSVLDQ LSELDELEAE
ADAWAPLAME TNDFEAIISL SKRTGDMFSD LDLKLYHYQD RYYLWIDFPD EMEPEDEENA
LSLLAEYLTF STQTQPMLEE YGKLILDGDV FAKVRHYF