ID   MECA_LACCB              Reviewed;         228 AA.
AC   B3WF81;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=LCABL_19540;
OS   Lacticaseibacillus casei (strain BL23) (Lactobacillus casei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=543734;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BL23;
RA   Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A.,
RA   Deutscher J.;
RT   "Lactobacillus casei BL23 complete genome sequence.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FM177140; CAQ67032.1; -; Genomic_DNA.
DR   RefSeq; WP_012491678.1; NC_010999.1.
DR   AlphaFoldDB; B3WF81; -.
DR   SMR; B3WF81; -.
DR   KEGG; lcb:LCABL_19540; -.
DR   HOGENOM; CLU_071496_2_0_9; -.
DR   OMA; EFFYTVM; -.
DR   OrthoDB; 1678325at2; -.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..228
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000137281"
FT   REGION          79..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   228 AA;  25709 MW;  4404BD5B798B0050 CRC64;
     MEMERINANT IRVMLGNDDL AQRGITVLDL LGNHKQIESF FYSILDEVDK DHTFATNEAV
     TFQVMPSQSG LELLISRSGQ KNDDSAADQT DDEGTDTQVP DYIRQQLQGL DASDQQDHQA
     VDEGGYIDAD KAPQTELVLK LKDFEDFISL ADTLRLEGGK SDLYRYKNAY YLVLTFYPNE
     ISSDEAHDQM AVAMEFGDRS PLSSAVLSEY GKRLMETSAL ETARYYFK