ID   MECA_LACP3              Reviewed;         228 AA.
AC   Q037W6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=LSEI_1734;
OS   Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 /
OS   CIP 107868 / KCTC 3260 / NRRL B-441) (Lactobacillus paracasei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=321967;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL
RC   B-441;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; CP000423; ABJ70506.1; -; Genomic_DNA.
DR   RefSeq; WP_003579619.1; NC_008526.1.
DR   RefSeq; YP_806948.1; NC_008526.1.
DR   AlphaFoldDB; Q037W6; -.
DR   SMR; Q037W6; -.
DR   STRING; 321967.LSEI_1734; -.
DR   EnsemblBacteria; ABJ70506; ABJ70506; LSEI_1734.
DR   GeneID; 61269930; -.
DR   KEGG; lca:LSEI_1734; -.
DR   PATRIC; fig|321967.11.peg.1713; -.
DR   HOGENOM; CLU_071496_2_0_9; -.
DR   OMA; EFFYTVM; -.
DR   Proteomes; UP000001651; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..228
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000065339"
SQ   SEQUENCE   228 AA;  25681 MW;  77F11CD2799391D3 CRC64;
     MEMERINANT IRVMLGNDDL AQRGITVLDL LGNHKQIESF FYSILDEVDK DHTFATNEAV
     TFQVMPSQSG LELLISKSGQ KNDDSAADQT DDEGTDTQVP DYIRQQLQGL DASDQQDHQA
     VDEGGYIDAD KAPQTELVLK LKDFEDFISL ADTLRLEGGK SDLYRYKNAY YLVLTFYPNE
     ISSDEAHDQM AVAMEFGDRS PLSSAVLSEY GKRLMETSAL ETARYYFK