MECA_LEUMM
ID MECA_LEUMM Reviewed; 235 AA.
AC Q03VH8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=LEUM_1703;
OS Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM
OS 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB
OS 8023 / NCTC 12954 / NRRL B-1118 / 37Y).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Leuconostoc.
OX NCBI_TaxID=203120;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523
RC / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y;
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC aggregated proteins to the ClpC protease or to other proteins involved
CC in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC proteins; the C-terminal domain interacts with ClpC.
CC -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC Rule:MF_01124}.
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DR EMBL; CP000414; ABJ62794.1; -; Genomic_DNA.
DR RefSeq; WP_011680318.1; NC_008531.1.
DR AlphaFoldDB; Q03VH8; -.
DR SMR; Q03VH8; -.
DR STRING; 203120.LEUM_1703; -.
DR EnsemblBacteria; ABJ62794; ABJ62794; LEUM_1703.
DR GeneID; 61175893; -.
DR KEGG; lme:LEUM_1703; -.
DR eggNOG; COG4862; Bacteria.
DR HOGENOM; CLU_071496_2_0_9; -.
DR OMA; EFFYTVM; -.
DR OrthoDB; 1678325at2; -.
DR Proteomes; UP000000362; Chromosome.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.1950; -; 1.
DR HAMAP; MF_01124; MecA; 1.
DR InterPro; IPR038471; MecA_C_sf.
DR InterPro; IPR008681; Neg-reg_MecA.
DR PANTHER; PTHR39161; PTHR39161; 1.
DR Pfam; PF05389; MecA; 1.
DR PIRSF; PIRSF029008; MecA; 1.
PE 3: Inferred from homology;
FT CHAIN 1..235
FT /note="Adapter protein MecA"
FT /id="PRO_1000065342"
FT REGION 113..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 235 AA; 27002 MW; FE4C2C8F763F9C36 CRC64;
MEKERINENT IRVMIDNSDL KDRGITVMEL LGNHEKIESF FYNILSEVDT EHDFEDDDQV
SFQILPNRNG LELFISRLDE ENKISDILDN ITNFSSKQPA NIDNISDKRR QELRQSDKGD
IVKSKVSSSD HKDGSQENFE NTQVILALSD FENAIAIANS LKIENLVSDL YLYEGAYYLN
LLVPDHSVSQ EQLKNELAIA LEFSRISHVT HEVLHEHGQL ILKHEALEKI KSLFS