ID   MECA_LIMRD              Reviewed;         223 AA.
AC   A5VJ12;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=Lreu_0568;
OS   Limosilactobacillus reuteri (strain DSM 20016) (Lactobacillus reuteri).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Limosilactobacillus.
OX   NCBI_TaxID=557436;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20016;
RX   PubMed=21379339; DOI=10.1371/journal.pgen.1001314;
RA   Frese S.A., Benson A.K., Tannock G.W., Loach D.M., Kim J., Zhang M.,
RA   Oh P.L., Heng N.C., Patil P.B., Juge N., Mackenzie D.A., Pearson B.M.,
RA   Lapidus A., Dalin E., Tice H., Goltsman E., Land M., Hauser L., Ivanova N.,
RA   Kyrpides N.C., Walter J.;
RT   "The evolution of host specialization in the vertebrate gut symbiont
RT   Lactobacillus reuteri.";
RL   PLoS Genet. 7:E1001314-E1001314(2011).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; CP000705; ABQ82836.1; -; Genomic_DNA.
DR   RefSeq; WP_003666878.1; NZ_AZDD01000049.1.
DR   AlphaFoldDB; A5VJ12; -.
DR   SMR; A5VJ12; -.
DR   STRING; 557436.Lreu_0568; -.
DR   PRIDE; A5VJ12; -.
DR   EnsemblBacteria; ABQ82836; ABQ82836; Lreu_0568.
DR   GeneID; 66470713; -.
DR   KEGG; lre:Lreu_0568; -.
DR   PATRIC; fig|557436.17.peg.1485; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_2_0_9; -.
DR   OMA; EFFYTVM; -.
DR   Proteomes; UP000001991; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..223
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000065340"
SQ   SEQUENCE   223 AA;  25701 MW;  8D5BD864636B5BC2 CRC64;
     MEMERINENT IRVLVDNDDL SARGITILDL LGDHQQIEDF FYSILKEVDT DHQFQNNDAV
     TFQVMPTNNG LELFISKNDS NFAGNEQHGP INDQVSKYIK QHLIQKNSPD QDQRKTAIND
     SEDNEIQHTN WQVITFDSFE DLIDFAKIAE SDDVSSYLYK YNDLYYLAIA YSDSILNSND
     VKDQLALAYE YGNPTATTVD FLSEHGKKIM SVSALHLIRH YFE