MECA_LISMC
ID MECA_LISMC Reviewed; 217 AA.
AC C1KXE5;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 46.
DE RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=Lm4b_02217;
OS Listeria monocytogenes serotype 4b (strain CLIP80459).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=568819;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIP80459;
RX PubMed=22530965; DOI=10.1186/1471-2164-13-144;
RA Hain T., Ghai R., Billion A., Kuenne C.T., Steinweg C., Izar B.,
RA Mohamed W., Mraheil M., Domann E., Schaffrath S., Karst U., Goesmann A.,
RA Oehm S., Puhler A., Merkl R., Vorwerk S., Glaser P., Garrido P.,
RA Rusniok C., Buchrieser C., Goebel W., Chakraborty T.;
RT "Comparative genomics and transcriptomics of lineages I, II, and III
RT strains of Listeria monocytogenes.";
RL BMC Genomics 13:144-144(2012).
CC -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC aggregated proteins to the ClpC protease or to other proteins involved
CC in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC proteins; the C-terminal domain interacts with ClpC.
CC -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC Rule:MF_01124}.
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DR EMBL; FM242711; CAS05974.1; -; Genomic_DNA.
DR RefSeq; WP_003724608.1; NC_012488.1.
DR AlphaFoldDB; C1KXE5; -.
DR SMR; C1KXE5; -.
DR PRIDE; C1KXE5; -.
DR KEGG; lmc:Lm4b_02217; -.
DR HOGENOM; CLU_071496_2_1_9; -.
DR OMA; EFFYTVM; -.
DR BioCyc; LMON568819:LM4B_RS11210-MON; -.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.1950; -; 1.
DR HAMAP; MF_01124; MecA; 1.
DR InterPro; IPR038471; MecA_C_sf.
DR InterPro; IPR008681; Neg-reg_MecA.
DR PANTHER; PTHR39161; PTHR39161; 1.
DR Pfam; PF05389; MecA; 1.
DR PIRSF; PIRSF029008; MecA; 1.
PE 3: Inferred from homology;
FT CHAIN 1..217
FT /note="Adapter protein MecA"
FT /id="PRO_1000213625"
SQ SEQUENCE 217 AA; 25355 MW; FD6292F1C1095F38 CRC64;
MEIERINEDT IKFYISYLDL EERGFNQEDV WYDREKSEEL FWDMMDELKY EEEFSPEGPL
WIQVQALKHG LEVFVTKATI GGKGEDGFDV TLSSPDELAE EKIEKLLEEN FNPVKKEALG
DDDTLEFILE FRDFEDAISL SRATGLENLV TKLYSYQGKY YLNVEFPENK YDESNIDNAV
SILLEYGLES NLTGYMLAEY GKVIFDVPAL KQIRKHF