ID   MECA_LISMO              Reviewed;         217 AA.
AC   Q9RGW9;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=lmo2190;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LO28 / Serovar 1/2c;
RX   PubMed=11004200; DOI=10.1128/jb.182.20.5931-5934.2000;
RA   Borezee E., Msadek T., Durant L., Berche P.;
RT   "Identification in Listeria monocytogenes of MecA, a homologue of the
RT   Bacillus subtilis competence regulatory protein.";
RL   J. Bacteriol. 182:5931-5934(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; AF103794; AAF21894.1; -; Genomic_DNA.
DR   EMBL; AL591982; CAD00268.1; -; Genomic_DNA.
DR   PIR; AF1348; AF1348.
DR   RefSeq; NP_465714.1; NC_003210.1.
DR   RefSeq; WP_003722314.1; NZ_CP023861.1.
DR   AlphaFoldDB; Q9RGW9; -.
DR   SMR; Q9RGW9; -.
DR   STRING; 169963.lmo2190; -.
DR   PaxDb; Q9RGW9; -.
DR   EnsemblBacteria; CAD00268; CAD00268; CAD00268.
DR   GeneID; 984925; -.
DR   KEGG; lmo:lmo2190; -.
DR   PATRIC; fig|169963.11.peg.2242; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_2_1_9; -.
DR   OMA; EFFYTVM; -.
DR   PhylomeDB; Q9RGW9; -.
DR   BioCyc; LMON169963:LMO2190-MON; -.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..217
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_0000212274"
SQ   SEQUENCE   217 AA;  25369 MW;  FCC8235ADBB8F588 CRC64;
     MEIERINEDT IKFYISYLDL EERGFNQEDV WYDREKSEEL FWDMMDELKY EEEFSPEGPL
     WIQVQALKHG LEVFVTKATI GGKGEDGFDV TLSSPDELAE EKIEKLLEEN FNPVKKEALG
     EDDTLEFILE FRDFEDAISL SRATGLENLV TKLYSYQGKY YLNVEFPENK YDESNIDNAV
     SILLEYGLES NLTGYMLAEY GKVIFDVPAL KQIRKHF