MECA_LISW6
ID MECA_LISW6 Reviewed; 217 AA.
AC A0AKU3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=lwe2207;
OS Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 /
OS NCTC 11857 / SLCC 5334 / V8).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=386043;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8;
RX PubMed=16936040; DOI=10.1128/jb.00758-06;
RA Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S.,
RA Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O.,
RA Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T.,
RA Lampidis R., Kreft J., Goebel W., Chakraborty T.;
RT "Whole-genome sequence of Listeria welshimeri reveals common steps in
RT genome reduction with Listeria innocua as compared to Listeria
RT monocytogenes.";
RL J. Bacteriol. 188:7405-7415(2006).
CC -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC aggregated proteins to the ClpC protease or to other proteins involved
CC in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC proteins; the C-terminal domain interacts with ClpC.
CC -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC Rule:MF_01124}.
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DR EMBL; AM263198; CAK21625.1; -; Genomic_DNA.
DR RefSeq; WP_011702961.1; NC_008555.1.
DR AlphaFoldDB; A0AKU3; -.
DR SMR; A0AKU3; -.
DR STRING; 386043.lwe2207; -.
DR EnsemblBacteria; CAK21625; CAK21625; lwe2207.
DR GeneID; 61190110; -.
DR KEGG; lwe:lwe2207; -.
DR eggNOG; COG4862; Bacteria.
DR HOGENOM; CLU_071496_2_1_9; -.
DR OMA; EFFYTVM; -.
DR OrthoDB; 1678325at2; -.
DR Proteomes; UP000000779; Chromosome.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.1950; -; 1.
DR HAMAP; MF_01124; MecA; 1.
DR InterPro; IPR038471; MecA_C_sf.
DR InterPro; IPR008681; Neg-reg_MecA.
DR PANTHER; PTHR39161; PTHR39161; 1.
DR Pfam; PF05389; MecA; 1.
DR PIRSF; PIRSF029008; MecA; 1.
PE 3: Inferred from homology;
FT CHAIN 1..217
FT /note="Adapter protein MecA"
FT /id="PRO_1000065343"
SQ SEQUENCE 217 AA; 25413 MW; 2BC6BE1E6D564203 CRC64;
MEIERINEDT IKFYISYLDL EERGFNQEDV WYDREKSEEL FWDMMDELKY EEEFSPEGPL
WIQVQALKHG LEVFVTKATI GGKGEDGFDV TLSSPDELAE EKIEKLLEEN FNPVKKESLG
EDDTLEFILE FRDFEDVISL SRATGLENLL TKLYSYQGKY YLNVEFPENK YDESNIDNAV
SILLEYGLES NLTGYMLAEY GKVIFDVPAL QQVRKHF