ID   MECA_LYSSC              Reviewed;         222 AA.
AC   B1HNX3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=Bsph_1217;
OS   Lysinibacillus sphaericus (strain C3-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX   NCBI_TaxID=444177;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C3-41;
RX   PubMed=18296527; DOI=10.1128/jb.01652-07;
RA   Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M.,
RA   Berry C., Yuan Z.;
RT   "Complete genome sequence of the mosquitocidal bacterium Bacillus
RT   sphaericus C3-41 and comparison with those of closely related Bacillus
RT   species.";
RL   J. Bacteriol. 190:2892-2902(2008).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; CP000817; ACA38825.1; -; Genomic_DNA.
DR   RefSeq; WP_008181512.1; NC_010382.1.
DR   AlphaFoldDB; B1HNX3; -.
DR   SMR; B1HNX3; -.
DR   EnsemblBacteria; ACA38825; ACA38825; Bsph_1217.
DR   GeneID; 29442711; -.
DR   KEGG; lsp:Bsph_1217; -.
DR   HOGENOM; CLU_071496_2_1_9; -.
DR   OMA; EFFYTVM; -.
DR   Proteomes; UP000002164; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045808; P:negative regulation of establishment of competence for transformation; IEA:UniProtKB-UniRule.
DR   GO; GO:0042174; P:negative regulation of sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..222
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000137283"
SQ   SEQUENCE   222 AA;  26446 MW;  EEEEABF8608C3A4F CRC64;
     MDIERVNENT LKLFITYNDI EDRGYSREEI WYNRAKGEQL FWDMIDEVNT EDYFDVEGPI
     WIHINASEVG LEIIVTRAHI LKDGETLDGH SNFDEHKEMF APFDEVGDDL LSQLTQFGDM
     DESELFMDTD IYVYKFKDID ELIPVAKRMT DELVDSSLFK YENWYYLVVD FGNADEELNR
     HDRNAVIKEF LTPSNFTIHR LEEYGEKIME FNCFETVRKY FA