ID   MECA_MACCJ              Reviewed;         220 AA.
AC   B9EAQ8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=MCCL_0612;
OS   Macrococcus caseolyticus (strain JCSC5402).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Macrococcus.
OX   NCBI_TaxID=458233;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC5402;
RX   PubMed=19074389; DOI=10.1128/jb.01058-08;
RA   Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.;
RT   "Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402,
RT   reflecting the ancestral genome of the human-pathogenic staphylococci.";
RL   J. Bacteriol. 191:1180-1190(2009).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; AP009484; BAH17319.1; -; Genomic_DNA.
DR   RefSeq; WP_012656520.1; NC_011999.1.
DR   AlphaFoldDB; B9EAQ8; -.
DR   SMR; B9EAQ8; -.
DR   STRING; 458233.MCCL_0612; -.
DR   EnsemblBacteria; BAH17319; BAH17319; MCCL_0612.
DR   GeneID; 61129507; -.
DR   KEGG; mcl:MCCL_0612; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_2_1_9; -.
DR   OMA; EFFYTVM; -.
DR   OrthoDB; 1678325at2; -.
DR   Proteomes; UP000001383; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..220
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000164053"
SQ   SEQUENCE   220 AA;  26539 MW;  0B8132BDAE3295F2 CRC64;
     MRIERVNEST LKFYLTYTDI EARGFKRDDL WTSRKKGEEF FWSVMEEVNQ EEDFFFDGPL
     WIQVHAFDKG IEVVVTKSKN DDLQLPEDDS DLNIDEKVND FINNSMHSDS ELRDLLMRAS
     EESTEQFFIV HFDDLEDVIQ FSYHNYEDVD IEDLLYMYEG KYYYYVEFDD HMSEDAIHSY
     IAHLLEYANE TQISHEQLDE YGKIVMSHNV KRQVKQYFKQ