ID   MECA_STAA8              Reviewed;         239 AA.
AC   Q2G1U5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   OrderedLocusNames=SAOUHSC_00935;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; CP000253; ABD30060.1; -; Genomic_DNA.
DR   RefSeq; WP_001217730.1; NZ_LS483365.1.
DR   RefSeq; YP_499488.1; NC_007795.1.
DR   PDB; 6EMW; EM; 11.00 A; e/f/g/h/i/j=1-90.
DR   PDBsum; 6EMW; -.
DR   AlphaFoldDB; Q2G1U5; -.
DR   SMR; Q2G1U5; -.
DR   STRING; 1280.SAXN108_0994; -.
DR   EnsemblBacteria; ABD30060; ABD30060; SAOUHSC_00935.
DR   GeneID; 3920764; -.
DR   KEGG; sao:SAOUHSC_00935; -.
DR   PATRIC; fig|93061.5.peg.856; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_2_1_9; -.
DR   OMA; EFFYTVM; -.
DR   PRO; PR:Q2G1U5; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome.
FT   CHAIN           1..239
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000065347"
FT   REGION          118..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..132
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   239 AA;  28325 MW;  49253EFCCFF5FB44 CRC64;
     MRIERVDDTT VKLFITYSDI EARGFSREDL WTNRKRGEEF FWSMMDEINE EEDFVVEGPL
     WIQVHAFEKG VEVTISKSKN EDMMNMSDDD ATDQFDEQVQ ELLAQTLEGE DQLEELFEQR
     TKEKEAQGSK RQKSSARKNT RTIIVKFNDL EDVINYAYHS NPITTEFEDL LYMVDGTYYY
     AVYFDSHVDQ EVINDSYSQL LEFAYPTDRT EVYLNDYAKI IMSHNVTAQV RRYFPETTE