MECA_STAAB
ID MECA_STAAB Reviewed; 239 AA.
AC Q2YWY4;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=SAB0865;
OS Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=273036;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bovine RF122 / ET3-1;
RX PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT "Molecular correlates of host specialization in Staphylococcus aureus.";
RL PLoS ONE 2:E1120-E1120(2007).
CC -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC aggregated proteins to the ClpC protease or to other proteins involved
CC in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC proteins; the C-terminal domain interacts with ClpC.
CC -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC Rule:MF_01124}.
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DR EMBL; AJ938182; CAI80553.1; -; Genomic_DNA.
DR RefSeq; WP_001217733.1; NC_007622.1.
DR AlphaFoldDB; Q2YWY4; -.
DR SMR; Q2YWY4; -.
DR KEGG; sab:SAB0865; -.
DR HOGENOM; CLU_071496_2_1_9; -.
DR OMA; EFFYTVM; -.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.1950; -; 1.
DR HAMAP; MF_01124; MecA; 1.
DR InterPro; IPR038471; MecA_C_sf.
DR InterPro; IPR008681; Neg-reg_MecA.
DR PANTHER; PTHR39161; PTHR39161; 1.
DR Pfam; PF05389; MecA; 1.
DR PIRSF; PIRSF029008; MecA; 1.
PE 3: Inferred from homology;
FT CHAIN 1..239
FT /note="Adapter protein MecA"
FT /id="PRO_1000065348"
FT REGION 118..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 239 AA; 28313 MW; FD646BE88EA5FB42 CRC64;
MRIERVDDTT VKLFITYSDI EARGFSREDL WTNRKRGEEF FWSMMDEINE EEDFVVEGPL
WIQVHAFEKG VEVTISKSKN EDMMNMSDDD ATDQFDEQVQ ELLAQTLEGE DQLEELFEQR
TKEKEAQGSK RQKSSARKNT RTIIVKFNDL EDVINYAYHT NPITTEFEDL LYMVDGTYYY
AVHFDSHVDQ EVINDSYSQL LEFAYPTDRT EVYLNDYAKI IMSHNVTAQV RRYFPETTE