ID   ARGR_STRPN              Reviewed;         148 AA.
AC   P0A2Y2; Q54870;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Arginine repressor;
GN   Name=argR; OrderedLocusNames=SP_2077;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=175;
RX   PubMed=3275608; DOI=10.1128/jb.170.1.190-196.1988;
RA   Priebe S.D., Hadi S.M., Greenberg B., Lacks S.A.;
RT   "Nucleotide sequence of the hexA gene for DNA mismatch repair in
RT   Streptococcus pneumoniae and homology of hexA to mutS of Escherichia coli
RT   and Salmonella typhimurium.";
RL   J. Bacteriol. 170:190-196(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Regulates arginine biosynthesis genes. {ECO:0000250}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis [regulation].
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ArgR family. {ECO:0000305}.
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DR   EMBL; M18729; AAA88596.1; -; Genomic_DNA.
DR   EMBL; AE005672; AAK76138.1; -; Genomic_DNA.
DR   PIR; A95243; A95243.
DR   PIR; B28667; B28667.
DR   RefSeq; WP_001231472.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P0A2Y2; -.
DR   SMR; P0A2Y2; -.
DR   STRING; 170187.SP_2077; -.
DR   EnsemblBacteria; AAK76138; AAK76138; SP_2077.
DR   GeneID; 60233214; -.
DR   KEGG; spn:SP_2077; -.
DR   eggNOG; COG1438; Bacteria.
DR   OMA; VVIHTEL; -.
DR   PhylomeDB; P0A2Y2; -.
DR   BioCyc; SPNE170187:G1FZB-2163-MON; -.
DR   UniPathway; UPA00068; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0034618; F:arginine binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0051259; P:protein complex oligomerization; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00173; Arg_repressor; 1.
DR   InterPro; IPR001669; Arg_repress.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR036251; Arg_repress_C_sf.
DR   InterPro; IPR020900; Arg_repress_DNA-bd.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34471; PTHR34471; 1.
DR   Pfam; PF01316; Arg_repressor; 1.
DR   Pfam; PF02863; Arg_repressor_C; 1.
DR   PRINTS; PR01467; ARGREPRESSOR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF55252; SSF55252; 1.
DR   TIGRFAMs; TIGR01529; argR_whole; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; DNA-binding;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..148
FT                   /note="Arginine repressor"
FT                   /id="PRO_0000205126"
SQ   SEQUENCE   148 AA;  17063 MW;  DB378918B5F7DCD0 CRC64;
     MRKRDRHQLI KKMITEEKLS TQKEIQDRLE AHNVCVTQTT LSRDLREIGL TKVKKNDMVY
     YVLVNETEKI DLVEFLSHHL EGVARAEFTL VLHTKLGEAS VLANIVDVNK DEWILGTVAG
     ANTLLVICRD QHVAKLMEDR LLDLMKDK