ID   MECA_STACT              Reviewed;         238 AA.
AC   B9DIR3;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=Sca_0598;
OS   Staphylococcus carnosus (strain TM300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=396513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TM300;
RX   PubMed=19060169; DOI=10.1128/aem.01982-08;
RA   Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C.,
RA   Goetz F.;
RT   "Genome analysis of the meat starter culture bacterium Staphylococcus
RT   carnosus TM300.";
RL   Appl. Environ. Microbiol. 75:811-822(2009).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; AM295250; CAL27512.1; -; Genomic_DNA.
DR   RefSeq; WP_015899855.1; NC_012121.1.
DR   AlphaFoldDB; B9DIR3; -.
DR   SMR; B9DIR3; -.
DR   STRING; 396513.SCA_0598; -.
DR   GeneID; 60545703; -.
DR   KEGG; sca:SCA_0598; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_2_1_9; -.
DR   OMA; EFFYTVM; -.
DR   OrthoDB; 1678325at2; -.
DR   BioCyc; SCAR396513:SCA_RS03050-MON; -.
DR   Proteomes; UP000000444; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..238
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000164054"
FT   REGION          108..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   238 AA;  28445 MW;  1F36C5F769B5A47D CRC64;
     MRIERVDDTT VKLFITYGDI ESRGFKREDL WTNRQRGEEF FWSMMEEINE EEDFVVEGPL
     WIQVHAFEKG VEVVISKSKN EEMMNMADDN MNNEFDRQLN ELLEQSFEDE NEESVQGNQQ
     QRRSHASDHS KRARHTNGRL VIVKFEDLES VIDYAHHSNQ PTDDFEDLLY MLNNEYYYAI
     HFDDNVGEEV INDFYSQLLE FTQPSDRSEM YLNDYAKIIM SHNVTAQVRR FFTDTEEI