ID   MECA_STAEQ              Reviewed;         240 AA.
AC   Q5HQH1;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=SERP0578;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; CP000029; AAW53980.1; -; Genomic_DNA.
DR   RefSeq; WP_001829308.1; NC_002976.3.
DR   AlphaFoldDB; Q5HQH1; -.
DR   SMR; Q5HQH1; -.
DR   STRING; 176279.SERP0578; -.
DR   EnsemblBacteria; AAW53980; AAW53980; SERP0578.
DR   GeneID; 50019172; -.
DR   KEGG; ser:SERP0578; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_2_1_9; -.
DR   OMA; EFFYTVM; -.
DR   OrthoDB; 1678325at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..240
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_0000212283"
FT   REGION          119..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   240 AA;  28716 MW;  631D2D17B32982DF CRC64;
     MRIERVDDTT VKLFITYSDI EARGFSREDL WSNRKRGEEF FWSMMDEINE EEDFVVEGPL
     WIQVHAFEKG VEVTISKSKN EDAMNMSDDD TNHQFDDQVN ELLAQTLEGE ESLEDLFEQR
     KQQKKNHQDK QQRRAHKPSN VRNIIVKFDD LEQVIDYAYH NNQNTDEFED LLYMIDNKYY
     YSIHFDDSVS QEMINDSYSQ LLEFAYPTDK TNIYLNDYAK IIMSHNVTSQ VRKYFTDTNE