MECA_STAES
ID MECA_STAES Reviewed; 240 AA.
AC Q8CPS8;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=SE_0688;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC aggregated proteins to the ClpC protease or to other proteins involved
CC in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC proteins; the C-terminal domain interacts with ClpC.
CC -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC Rule:MF_01124}.
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DR EMBL; AE015929; AAO04285.1; -; Genomic_DNA.
DR RefSeq; NP_764243.1; NC_004461.1.
DR RefSeq; WP_001829308.1; NZ_WBME01000019.1.
DR AlphaFoldDB; Q8CPS8; -.
DR SMR; Q8CPS8; -.
DR STRING; 176280.SE_0688; -.
DR EnsemblBacteria; AAO04285; AAO04285; SE_0688.
DR GeneID; 50019172; -.
DR KEGG; sep:SE_0688; -.
DR PATRIC; fig|176280.10.peg.662; -.
DR eggNOG; COG4862; Bacteria.
DR HOGENOM; CLU_071496_2_1_9; -.
DR OMA; EFFYTVM; -.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.1950; -; 1.
DR HAMAP; MF_01124; MecA; 1.
DR InterPro; IPR038471; MecA_C_sf.
DR InterPro; IPR008681; Neg-reg_MecA.
DR PANTHER; PTHR39161; PTHR39161; 1.
DR Pfam; PF05389; MecA; 1.
DR PIRSF; PIRSF029008; MecA; 1.
PE 3: Inferred from homology;
FT CHAIN 1..240
FT /note="Adapter protein MecA"
FT /id="PRO_0000212282"
FT REGION 119..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 240 AA; 28716 MW; 631D2D17B32982DF CRC64;
MRIERVDDTT VKLFITYSDI EARGFSREDL WSNRKRGEEF FWSMMDEINE EEDFVVEGPL
WIQVHAFEKG VEVTISKSKN EDAMNMSDDD TNHQFDDQVN ELLAQTLEGE ESLEDLFEQR
KQQKKNHQDK QQRRAHKPSN VRNIIVKFDD LEQVIDYAYH NNQNTDEFED LLYMIDNKYY
YSIHFDDSVS QEMINDSYSQ LLEFAYPTDK TNIYLNDYAK IIMSHNVTSQ VRKYFTDTNE