ID   MECA_STAS1              Reviewed;         238 AA.
AC   Q49WC7;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=SSP1787;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; AP008934; BAE18932.1; -; Genomic_DNA.
DR   RefSeq; WP_011303487.1; NZ_MTGA01000039.1.
DR   AlphaFoldDB; Q49WC7; -.
DR   SMR; Q49WC7; -.
DR   STRING; 342451.SSP1787; -.
DR   EnsemblBacteria; BAE18932; BAE18932; SSP1787.
DR   KEGG; ssp:SSP1787; -.
DR   PATRIC; fig|342451.11.peg.1783; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_2_1_9; -.
DR   OMA; EFFYTVM; -.
DR   OrthoDB; 1678325at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..238
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_0000212285"
FT   REGION          120..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   238 AA;  28583 MW;  A23A7F15DF25C1FF CRC64;
     MRIERVDDTT VKLFITYSDI EARGFKREDL WTNRKRGEEF FWNMMEEINE EEDFVVEGPL
     WIQVHAFEKG VEVTISKSKN EDLINMSDED NEQLDYQVND LLSQTFDQDD SLEDLFDQRQ
     QQKDNKQNQD QNERNRQNTR TVIVKFNDLE EVIEYAHYNN QVTDEFEDLL YSLNNVYYYA
     VHYDETVDQE TINDSYSQLL EFAYPTDKSE VYLNDYAKII MSHNVASQVR RYFPNTEA