ID   MECA_STRA3              Reviewed;         251 AA.
AC   Q8E7L9;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=gbs0135;
OS   Streptococcus agalactiae serotype III (strain NEM316).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=211110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEM316;
RX   PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA   Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T.,
RA   Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.;
RT   "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive
RT   neonatal disease.";
RL   Mol. Microbiol. 45:1499-1513(2002).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL766844; CAD45780.1; -; Genomic_DNA.
DR   RefSeq; WP_000425371.1; NC_004368.1.
DR   AlphaFoldDB; Q8E7L9; -.
DR   SMR; Q8E7L9; -.
DR   STRING; 211110.gbs0135; -.
DR   EnsemblBacteria; CAD45780; CAD45780; CAD45780.
DR   GeneID; 66885116; -.
DR   KEGG; san:gbs0135; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_1_0_9; -.
DR   OMA; EFFYTVM; -.
DR   Proteomes; UP000000823; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..251
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_0000212286"
SQ   SEQUENCE   251 AA;  29055 MW;  6827F24CB5F9E906 CRC64;
     MEMKQISETT LKITISMEDL EDRGMELKDF LIPQEKTEEF FYSVMDELDL PENFKNSGML
     SFRVTPKKDR IDVFVTKSEL SKDLNLEELA DLGDISKMSP EDFFKTLEQS MLEKGDTDAH
     AKLAEIENMM DKATQEVVEE NVSEEQPEKE VETIGYVHYV FDFDNIEAVV RFSQTIDFPI
     EASELYKNGK GYHMTILLDL ENQPSYFANL MYARMLEHAN VGTKTRAYLK EHSIQLIHDD
     AISKLQMIEM G