ID   MECA_STRGC              Reviewed;         242 AA.
AC   A8AYY6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=SGO_1724;
OS   Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 /
OS   DL1 / V288).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=467705;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288;
RX   PubMed=17720781; DOI=10.1128/jb.01023-07;
RA   Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.;
RT   "Genome-wide transcriptional changes in Streptococcus gordonii in response
RT   to competence signaling peptide.";
RL   J. Bacteriol. 189:7799-7807(2007).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; CP000725; ABV09150.1; -; Genomic_DNA.
DR   RefSeq; WP_012130768.1; NC_009785.1.
DR   AlphaFoldDB; A8AYY6; -.
DR   SMR; A8AYY6; -.
DR   STRING; 467705.SGO_1724; -.
DR   EnsemblBacteria; ABV09150; ABV09150; SGO_1724.
DR   KEGG; sgo:SGO_1724; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_1_0_9; -.
DR   OMA; EFFYTVM; -.
DR   Proteomes; UP000001131; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..242
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000085012"
SQ   SEQUENCE   242 AA;  28310 MW;  92E11C73294AE1D7 CRC64;
     MEVKQISEST IKITIKLEDL EEHGMEMADF LVPQEKTEEF FYTILDELEM PESFLDSGML
     SFRVTPKPDK LDVFVTKSKV DKNLNFEDLA DLPDMDELSQ MTPDEFLKTL EKNIFEKSRD
     DIDAVQMLEK AEEEDTSEPE EGQEQDRYIY YILRFSDLKN LIAFTKTVDY PVDTSELYKM
     DQRYYLTILV DIEGRPSRYP AWLLAAMREH AEDTDTTRAL LQEHGHLLIV TDAVQHLQKV
     NC