ID   MECA_STRP1              Reviewed;         253 AA.
AC   P60187; Q490W0; Q9A1G7;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   OrderedLocusNames=SPy_0281, M5005_Spy0239;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; AE004092; AAK33353.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ50858.1; -; Genomic_DNA.
DR   RefSeq; NP_268632.1; NC_002737.2.
DR   AlphaFoldDB; P60187; -.
DR   SMR; P60187; -.
DR   STRING; 1314.HKU360_00279; -.
DR   PaxDb; P60187; -.
DR   EnsemblBacteria; AAK33353; AAK33353; SPy_0281.
DR   KEGG; spy:SPy_0281; -.
DR   KEGG; spz:M5005_Spy0239; -.
DR   PATRIC; fig|160490.10.peg.247; -.
DR   HOGENOM; CLU_071496_1_0_9; -.
DR   OMA; EFFYTVM; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..253
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_0000212291"
SQ   SEQUENCE   253 AA;  29052 MW;  338A2EFD5750B9EE CRC64;
     MEMKQISETT LKITISMDDL EERGMELKDF LIPQEKTEEF FYSVMDELDL PDNFKDSGML
     SFRVTPRKDR LDVFVTKSEI NKDINLEDLA EFGDMSQMTP EDFFKSLEQS MREKGDVKAH
     EKLEKIEEIM EDVVEATLAN QSEAADPSTN HESEPLDYVH YVLDFSTITE AVAFAKTIDF
     SIEASELYKG SNCYHMTILL DVQQQPSYFA NVMYARLIEH ANPGSKTRAY LQEHGLQLML
     DGAVEQLQKI ELG