ID   MECA_STRP2              Reviewed;         245 AA.
AC   Q04JY5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=SPD_1196;
OS   Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=373153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D39 / NCTC 7466;
RX   PubMed=17041037; DOI=10.1128/jb.01148-06;
RA   Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M.,
RA   Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.;
RT   "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus
RT   pneumoniae and comparison with that of unencapsulated laboratory strain
RT   R6.";
RL   J. Bacteriol. 189:38-51(2007).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; CP000410; ABJ53985.1; -; Genomic_DNA.
DR   RefSeq; WP_000782664.1; NC_008533.2.
DR   AlphaFoldDB; Q04JY5; -.
DR   SMR; Q04JY5; -.
DR   STRING; 373153.SPD_1196; -.
DR   EnsemblBacteria; ABJ53985; ABJ53985; SPD_1196.
DR   GeneID; 60234386; -.
DR   KEGG; spd:SPD_1196; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_1_0_9; -.
DR   OMA; EFFYTVM; -.
DR   OrthoDB; 1678325at2; -.
DR   BioCyc; SPNE373153:G1G6V-1293-MON; -.
DR   Proteomes; UP000001452; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..245
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000065350"
SQ   SEQUENCE   245 AA;  28363 MW;  367094133495F589 CRC64;
     MKMKQISDTT LKITISLEDL MDRGMEIADF LVPQEKTEEF FYAILDELEM PDSFLDTGML
     SFRVTPKPDK VDVFVTKSKI DQNLDFEDLS DLPDMEELAQ MSPDEFIKTL EKSIADKTKD
     DIEAIQSLEQ VEAKEEEQEQ AEQEAESKKE PYIYYILSFA KLADLVAFAK TVTFEMETSE
     LYKMNERYYL TILVDIENHP SPYPAWLLAR MREFADDSDI SRSVLQEYGQ VLMSHDAVLN
     LQKIG