ID   MECA_STRP6              Reviewed;         253 AA.
AC   Q5XDV7;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=M6_Spy0271;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT86406.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000003; AAT86406.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011106593.1; NC_006086.1.
DR   AlphaFoldDB; Q5XDV7; -.
DR   SMR; Q5XDV7; -.
DR   EnsemblBacteria; AAT86406; AAT86406; M6_Spy0271.
DR   KEGG; spa:M6_Spy0271; -.
DR   HOGENOM; CLU_071496_1_0_9; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..253
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_0000212293"
SQ   SEQUENCE   253 AA;  29052 MW;  3A983B1D5750AC0E CRC64;
     MEMKQISETT LKITISMDDL EERGMELKDF LIPQEKTEEF FYSVMDELDL PDNFKDSGML
     SFRVTPRKDR LDVFVTKSEI NKDINLEDLA EFGDMSQMTP EDFFKSLEQS MREKGDVKAH
     EKLEQIEEIM EDVVEATLAN QSEAADPSTN HESEPLDYVH YVLDFSTITE AVAFAKTIDF
     SIEASELYKG SNCYHMTILL DVQQQPSYFA NVMYARLIEH ANPGSKTRAY LQEHGLQLML
     DGAVEQLQKI ELG