ID   MECA_STRP7              Reviewed;         245 AA.
AC   C1C7W3;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   OrderedLocusNames=SP70585_1401;
OS   Streptococcus pneumoniae (strain 70585).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=488221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70585;
RX   PubMed=21034474; DOI=10.1186/gb-2010-11-10-r107;
RA   Donati C., Hiller N.L., Tettelin H., Muzzi A., Croucher N.J.,
RA   Angiuoli S.V., Oggioni M., Dunning Hotopp J.C., Hu F.Z., Riley D.R.,
RA   Covacci A., Mitchell T.J., Bentley S.D., Kilian M., Ehrlich G.D.,
RA   Rappuoli R., Moxon E.R., Masignani V.;
RT   "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and
RT   closely related species.";
RL   Genome Biol. 11:R107.1-R107.19(2010).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; CP000918; ACO16267.1; -; Genomic_DNA.
DR   RefSeq; WP_000782680.1; NC_012468.1.
DR   AlphaFoldDB; C1C7W3; -.
DR   SMR; C1C7W3; -.
DR   EnsemblBacteria; ACO16267; ACO16267; SP70585_1401.
DR   KEGG; snm:SP70585_1401; -.
DR   HOGENOM; CLU_071496_1_0_9; -.
DR   OMA; EFFYTVM; -.
DR   Proteomes; UP000002211; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..245
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000164055"
SQ   SEQUENCE   245 AA;  28409 MW;  3E50CF2729A135EB CRC64;
     MKMKQISDTT LKITMSLEDL MDRGMEIADF LVPQEKTEEF FYAILDELEM PDSFLDTGML
     SFRVTPKPDK VDVFVTKSKI DQNLDFEDLS DLPDMEELAQ MSPDEFIKTL EKSIADKTKD
     DIEAIQSLEQ VEAKEEEQEQ AEQEAESKKE PYIYYILSFA KLADLVVFAK TVTFEMETSE
     LYKMNERYYL TILVDIENHP SPYPAWLLAR MREFADDSDI SRSVLQEYGQ VLMSHDAVLN
     LQKIG