ID   MECA_STRPN              Reviewed;         245 AA.
AC   Q97Q68;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=SP_1362;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- INTERACTION:
CC       Q97Q68; P63544: apt; NbExp=2; IntAct=EBI-2207260, EBI-2207316;
CC       Q97Q68; Q97SE5: gatC; NbExp=2; IntAct=EBI-2207260, EBI-2207053;
CC       Q97Q68; Q97NV3: groES; NbExp=2; IntAct=EBI-2207260, EBI-2206949;
CC       Q97Q68; A0A0H2UNP1: lacF-1; NbExp=2; IntAct=EBI-2207260, EBI-2207447;
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005672; AAK75460.1; -; Genomic_DNA.
DR   PIR; C95158; C95158.
DR   RefSeq; WP_000782668.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q97Q68; -.
DR   SMR; Q97Q68; -.
DR   IntAct; Q97Q68; 4.
DR   STRING; 170187.SP_1362; -.
DR   EnsemblBacteria; AAK75460; AAK75460; SP_1362.
DR   KEGG; spn:SP_1362; -.
DR   eggNOG; COG4862; Bacteria.
DR   OMA; EFFYTVM; -.
DR   PhylomeDB; Q97Q68; -.
DR   BioCyc; SPNE170187:G1FZB-1370-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   1: Evidence at protein level;
FT   CHAIN           1..245
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_0000212289"
SQ   SEQUENCE   245 AA;  28391 MW;  58541F7E824E811B CRC64;
     MKMKQISDTT LKITISLEDL MDRGMEIADF LVPQEKTEEF FYAILDELEM PDSFLDTGML
     SFRVTPKPDK VDVFVTKSKI DQNLDFEDLS DLPDMEELAQ MSPDEFIKTL EKSIADKTKD
     DIEAIQSLEQ VEVKEEEQEQ AEQEAESKKE PYIYYILSFA KLADLVAFAK TVTFEMETSE
     LYKMNERYYL TILVDIENHP SPYPAWLLAR MREFADDSDI SRSVLQEYGQ VLMSHDAVLN
     LQKIG