ID   MECA_STRPZ              Reviewed;         253 AA.
AC   B5XJR8;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=Spy49_0240;
OS   Streptococcus pyogenes serotype M49 (strain NZ131).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=471876;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NZ131;
RX   PubMed=18820018; DOI=10.1128/jb.00672-08;
RA   McShan W.M., Ferretti J.J., Karasawa T., Suvorov A.N., Lin S., Qin B.,
RA   Jia H., Kenton S., Najar F., Wu H., Scott J., Roe B.A., Savic D.J.;
RT   "Genome sequence of a nephritogenic and highly transformable M49 strain of
RT   Streptococcus pyogenes.";
RL   J. Bacteriol. 190:7773-7785(2008).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; CP000829; ACI60580.1; -; Genomic_DNA.
DR   RefSeq; WP_002986029.1; NC_011375.1.
DR   AlphaFoldDB; B5XJR8; -.
DR   SMR; B5XJR8; -.
DR   EnsemblBacteria; ACI60580; ACI60580; Spy49_0240.
DR   GeneID; 57852069; -.
DR   KEGG; soz:Spy49_0240; -.
DR   HOGENOM; CLU_071496_1_0_9; -.
DR   OMA; EFFYTVM; -.
DR   Proteomes; UP000001039; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..253
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000137286"
SQ   SEQUENCE   253 AA;  29052 MW;  338A2EFD5750B9EE CRC64;
     MEMKQISETT LKITISMDDL EERGMELKDF LIPQEKTEEF FYSVMDELDL PDNFKDSGML
     SFRVTPRKDR LDVFVTKSEI NKDINLEDLA EFGDMSQMTP EDFFKSLEQS MREKGDVKAH
     EKLEKIEEIM EDVVEATLAN QSEAADPSTN HESEPLDYVH YVLDFSTITE AVAFAKTIDF
     SIEASELYKG SNCYHMTILL DVQQQPSYFA NVMYARLIEH ANPGSKTRAY LQEHGLQLML
     DGAVEQLQKI ELG