ID   MECA_STRSV              Reviewed;         250 AA.
AC   A3CQ78;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=SSA_1958;
OS   Streptococcus sanguinis (strain SK36).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=388919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK36;
RX   PubMed=17277061; DOI=10.1128/jb.01808-06;
RA   Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA   Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA   Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT   "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL   J. Bacteriol. 189:3166-3175(2007).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; CP000387; ABN45333.1; -; Genomic_DNA.
DR   RefSeq; WP_011837465.1; NC_009009.1.
DR   RefSeq; YP_001035883.1; NC_009009.1.
DR   AlphaFoldDB; A3CQ78; -.
DR   SMR; A3CQ78; -.
DR   STRING; 388919.SSA_1958; -.
DR   EnsemblBacteria; ABN45333; ABN45333; SSA_1958.
DR   KEGG; ssa:SSA_1958; -.
DR   PATRIC; fig|388919.9.peg.1857; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_1_0_9; -.
DR   OMA; EFFYTVM; -.
DR   OrthoDB; 1678325at2; -.
DR   Proteomes; UP000002148; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..250
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000065352"
SQ   SEQUENCE   250 AA;  28853 MW;  E20EDA39CE16D49C CRC64;
     MEMKQISDST IKITIQLEDL EKRGMEMADF LVPQEKTEEF FYTILDELEM PDNFLDSGML
     SFRVTPKPDK VDVFVTKSKL DKNLSFEDLA DLPDMDELSH MSPDEFLKTL EKSIFEKSKE
     DIEAVKSLET AEAEEREQLS QEAADEQSAE NAERYIYYIL RFEDIKAAAA FAQTVDYKID
     LSELYKYDSA YYLTILVDVE GFPERYPAWL LAKMREFADD SDITRAVLQE HGHLLLVTDA
     VSGLQKVECL