ID   MECA_STRT2              Reviewed;         249 AA.
AC   Q5M699;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=stu0162;
OS   Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=264199;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-250 / LMG 18311;
RX   PubMed=15543133; DOI=10.1038/nbt1034;
RA   Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D.,
RA   Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M.,
RA   Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D.,
RA   Hancy F., Burteau S., Boutry M., Delcour J., Goffeau A., Hols P.;
RT   "Complete sequence and comparative genome analysis of the dairy bacterium
RT   Streptococcus thermophilus.";
RL   Nat. Biotechnol. 22:1554-1558(2004).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; CP000023; AAV59887.1; -; Genomic_DNA.
DR   RefSeq; WP_011225365.1; NC_006448.1.
DR   AlphaFoldDB; Q5M699; -.
DR   SMR; Q5M699; -.
DR   STRING; 264199.stu0162; -.
DR   EnsemblBacteria; AAV59887; AAV59887; stu0162.
DR   GeneID; 66898106; -.
DR   KEGG; stl:stu0162; -.
DR   PATRIC; fig|264199.4.peg.168; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_1_0_9; -.
DR   OMA; EFFYTVM; -.
DR   Proteomes; UP000001170; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:CACAO.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..249
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000065354"
SQ   SEQUENCE   249 AA;  29158 MW;  4DD391B07DD3186A CRC64;
     MEMKQINETT LKIMITMEDL EEHGMELKDF LIPQEKTEEF FYTVMDELDL PDNFKNSGML
     SFRVTPRKDR VDVFVTKSDL KEALDFNDLS DMEDYSGLSP EEFLKALEDN FMDKGDIEAH
     HKLEEHDKTL KEVDETMTEP AKEVAEETIR EDYTHYVLAF SDFDQVVTFA QGLKNVSVEG
     SEFYKLGDVY YMTILLYLAD EPDYYANNMY ARFLEYANVA DRTRPYLQEH ATILMEEDAL
     PVLQATKWS