ID   MECA_STRU0              Reviewed;         252 AA.
AC   B9DTL0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=SUB0340;
OS   Streptococcus uberis (strain ATCC BAA-854 / 0140J).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=218495;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-854 / 0140J;
RX   PubMed=19175920; DOI=10.1186/1471-2164-10-54;
RA   Ward P.N., Holden M.T.G., Leigh J.A., Lennard N., Bignell A., Barron A.,
RA   Clark L., Quail M.A., Woodward J., Barrell B.G., Egan S.A., Field T.R.,
RA   Maskell D., Kehoe M., Dowson C.G., Chanter N., Whatmore A.M., Bentley S.D.,
RA   Parkhill J.;
RT   "Evidence for niche adaptation in the genome of the bovine pathogen
RT   Streptococcus uberis.";
RL   BMC Genomics 10:54-54(2009).
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01124}.
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DR   EMBL; AM946015; CAR40923.1; -; Genomic_DNA.
DR   RefSeq; WP_012657878.1; NC_012004.1.
DR   AlphaFoldDB; B9DTL0; -.
DR   SMR; B9DTL0; -.
DR   STRING; 218495.SUB0340; -.
DR   EnsemblBacteria; CAR40923; CAR40923; SUB0340.
DR   KEGG; sub:SUB0340; -.
DR   eggNOG; COG4862; Bacteria.
DR   HOGENOM; CLU_071496_1_0_9; -.
DR   OMA; EFFYTVM; -.
DR   OrthoDB; 1678325at2; -.
DR   Proteomes; UP000000449; Chromosome.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; PTHR39161; 1.
DR   Pfam; PF05389; MecA; 1.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..252
FT                   /note="Adapter protein MecA"
FT                   /id="PRO_1000164057"
SQ   SEQUENCE   252 AA;  29392 MW;  62A9103F97D21084 CRC64;
     MEMKQISETT LKITISMDDL EERGMELKDF LIPQEKTEEF FYTVMDELDL PDNFKDSGML
     SFRVTPRKDR LDVFVTKSDL NKEINFDDLA DLGDVSQMTP EDFFKTIEKS MIEKGDVNAH
     EKLEKIEEMM EEAVDAVMTQ NAEEQKEEES PFEPLDYVHY VLDFMTIQDA ITFSKTVTFP
     IEASELYKSS DRYHMTILLD IQNQPSYYAN VMYARLIEHA LPGSKTRAYL QEHAHQLLED
     HAVTELQKVE LV