ID   MECR_STAAM              Reviewed;         585 AA.
AC   P0A0A9; P26597; P72353;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Methicillin resistance mecR1 protein;
GN   Name=mecR1; Synonyms=mecR; OrderedLocusNames=SAV0042;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Penicillin-interactive protein and potential antirepressor.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase M56 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000017; BAB56204.1; -; Genomic_DNA.
DR   RefSeq; WP_000952923.1; NG_051163.1.
DR   AlphaFoldDB; P0A0A9; -.
DR   SMR; P0A0A9; -.
DR   MEROPS; M56.002; -.
DR   World-2DPAGE; 0002:P0A0A9; -.
DR   PaxDb; P0A0A9; -.
DR   EnsemblBacteria; BAB56204; BAB56204; SAV0042.
DR   KEGG; sav:SAV0042; -.
DR   HOGENOM; CLU_035412_0_2_9; -.
DR   OMA; VNGWFIG; -.
DR   PhylomeDB; P0A0A9; -.
DR   BioCyc; SAUR158878:SAV_RS00345-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; -; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   InterPro; IPR008756; Peptidase_M56.
DR   Pfam; PF05569; Peptidase_M56; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance.
FT   CHAIN           1..585
FT                   /note="Methicillin resistance mecR1 protein"
FT                   /id="PRO_0000096349"
FT   REGION          351..585
FT                   /note="Beta-lactamase-like"
SQ   SEQUENCE   585 AA;  68503 MW;  D3E1075FC9AD57C0 CRC64;
     MLSSFLMLSI ISSLLTICVI FLVRMLYIKY TQNIMSHKIW LLVLVSTLIP LIPFYKISNF
     TFSKDMMNRN VSDTTSSVSH MLDGQQSSVT KDLAINVNQF ETSNITYMIL LIWVFGSLLC
     LFYMIKAFRQ IDVIKSSSLE SSYLNERLKV CQSKMQFYKK HITISYSSNI DNPMVFGLVK
     SQIVLPTVVV ETMNDKEIEY IILHELSHVK SHDLIFNQLY VVFKMIFWFN PALYISKTMM
     DNDCEKVCDR NVLKILNRHE HIRYGESILK CSILKSQHIN NVAAQYLLGF NSNIKERVKY
     IALYDSMPKP NRNKRIVAYI VCSISLLIQA PLLSAHVQQD KYETNVSYKK LNQLAPYFKG
     FDGSFVLYNE REQAYSIYNE PESKQRYSPN STYKIYLALM AFDQNLLSLN HTEQQWDKHQ
     YPFKEWNQDQ NLNSSMKYSV NWYYENLNKH LRQDEVKSYL DLIEYGNEEI SGNENYWNES
     SLKISAIEQV NLLKNMKQHN MHFDNKAIEK VENSMTLKQK DTYKYVGKTG TGIVNHKEAN
     GWFVGYVETK DNTYYFATHL KGEDNANGEK AQQISERILK EMELI