ID   ARGR_THEMA              Reviewed;         152 AA.
AC   Q9WW19;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 142.
DE   RecName: Full=Arginine repressor;
GN   Name=argR; OrderedLocusNames=TM_0371;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10732680; DOI=10.1007/pl00008670;
RA   Dimova D., Weigel P., Takahashi M., Marc F., Van Duyne G.D., Sakanyan V.;
RT   "Thermostability, oligomerization and DNA-binding properties of the
RT   regulatory protein ArgR from the hyperthermophilic bacterium Thermotoga
RT   neapolitana.";
RL   Mol. Gen. Genet. 263:119-130(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- FUNCTION: Regulates arginine biosynthesis genes. {ECO:0000250}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis [regulation].
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ArgR family. {ECO:0000305}.
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DR   EMBL; AJ132286; CAB45262.1; -; Genomic_DNA.
DR   EMBL; AE000512; AAD35458.1; -; Genomic_DNA.
DR   PIR; A72385; A72385.
DR   RefSeq; NP_228182.1; NC_000853.1.
DR   RefSeq; WP_004083185.1; NZ_CP011107.1.
DR   AlphaFoldDB; Q9WW19; -.
DR   SMR; Q9WW19; -.
DR   STRING; 243274.THEMA_02860; -.
DR   EnsemblBacteria; AAD35458; AAD35458; TM_0371.
DR   KEGG; tma:TM0371; -.
DR   eggNOG; COG1438; Bacteria.
DR   InParanoid; Q9WW19; -.
DR   OMA; IMGTICG; -.
DR   OrthoDB; 1640037at2; -.
DR   UniPathway; UPA00068; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0034618; F:arginine binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0051259; P:protein complex oligomerization; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00173; Arg_repressor; 1.
DR   InterPro; IPR001669; Arg_repress.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR036251; Arg_repress_C_sf.
DR   InterPro; IPR020900; Arg_repress_DNA-bd.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34471; PTHR34471; 1.
DR   Pfam; PF01316; Arg_repressor; 1.
DR   Pfam; PF02863; Arg_repressor_C; 1.
DR   PRINTS; PR01467; ARGREPRESSOR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF55252; SSF55252; 1.
DR   TIGRFAMs; TIGR01529; argR_whole; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; DNA-binding;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..152
FT                   /note="Arginine repressor"
FT                   /id="PRO_0000205136"
SQ   SEQUENCE   152 AA;  17222 MW;  BCD5384934D490E9 CRC64;
     MKISKKRRQE LIRKIIHEKK ISNQFQIVEE LKKYGIKAVQ PTVARDLKEI GAVKIMDESG
     NYVYKLLDET PVIDPWKELK RNFKSFVESI DRAGNLIVIK TIPGTASGIA RVIDRLDIDE
     IVGTLAGDDT IFVAVRDPES CEKIVEKLSS IL