ID   MED10_CAEEL             Reviewed;         173 AA.
AC   P45966;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 10;
DE   AltName: Full=CeMED10;
DE   AltName: Full=CeNUT2;
DE   AltName: Full=Mediator complex subunit 10;
GN   Name=mdt-10; ORFNames=T09A5.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=10611325; DOI=10.1073/pnas.96.26.14990;
RA   Kwon J.Y., Park J.M., Gim B.S., Han S.J., Lee J., Kim Y.-J.;
RT   "Caenorhabditis elegans mediator complexes are required for developmental-
RT   specific transcriptional activation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:14990-14995(1999).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). Required for
CC       germ cell development and for transcriptional activation of certain
CC       stage-specific inducible promoters. {ECO:0000250,
CC       ECO:0000269|PubMed:10611325}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10611325}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 10 family.
CC       {ECO:0000305}.
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DR   EMBL; Z36753; CAA85334.1; -; Genomic_DNA.
DR   PIR; T24720; T24720.
DR   RefSeq; NP_495650.2; NM_063249.5.
DR   AlphaFoldDB; P45966; -.
DR   SMR; P45966; -.
DR   BioGRID; 52979; 2.
DR   IntAct; P45966; 4.
DR   STRING; 6239.T09A5.6.1; -.
DR   EPD; P45966; -.
DR   PaxDb; P45966; -.
DR   PeptideAtlas; P45966; -.
DR   EnsemblMetazoa; T09A5.6.1; T09A5.6.1; WBGene00007014.
DR   GeneID; 188311; -.
DR   KEGG; cel:CELE_T09A5.6; -.
DR   UCSC; T09A5.6; c. elegans.
DR   CTD; 188311; -.
DR   WormBase; T09A5.6; CE51730; WBGene00007014; mdt-10.
DR   eggNOG; KOG3046; Eukaryota.
DR   GeneTree; ENSGT00960000187808; -.
DR   HOGENOM; CLU_096169_3_0_1; -.
DR   InParanoid; P45966; -.
DR   OMA; YSKHCME; -.
DR   OrthoDB; 1403581at2759; -.
DR   PhylomeDB; P45966; -.
DR   PRO; PR:P45966; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00007014; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019145; Mediator_Med10.
DR   Pfam; PF09748; Med10; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..173
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   10"
FT                   /id="PRO_0000065455"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   173 AA;  20829 MW;  928DCB94C1DD2E1A CRC64;
     MVQQQQQSQQ RMMELHERND REKLARKTEK EREEERRKQE DDKILQLEKK LEEFQENARF
     IGDLASNFQT KYQDALNGRI YTLVRGLQDL DRMKGTFSDK KVPLDLLPYL DDGKNPCLYS
     KHCMEKTLEK NKAVNGKIEI YKKFRAHLMK EFSEEMPDLV MYYRSIREDL DLS