MED10_CHAGB
ID MED10_CHAGB Reviewed; 167 AA.
AC Q2H8S0;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 10;
DE AltName: Full=Mediator complex subunit 10;
GN Name=NUT2; Synonyms=MED10; ORFNames=CHGG_03384;
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 10 family.
CC {ECO:0000305}.
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DR EMBL; CH408030; EAQ91449.1; -; Genomic_DNA.
DR RefSeq; XP_001229900.1; XM_001229899.1.
DR AlphaFoldDB; Q2H8S0; -.
DR SMR; Q2H8S0; -.
DR STRING; 38033.XP_001229900.1; -.
DR EnsemblFungi; EAQ91449; EAQ91449; CHGG_03384.
DR GeneID; 4388777; -.
DR eggNOG; KOG3046; Eukaryota.
DR HOGENOM; CLU_096169_0_0_1; -.
DR InParanoid; Q2H8S0; -.
DR OMA; QYQRAKM; -.
DR OrthoDB; 1403581at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019145; Mediator_Med10.
DR Pfam; PF09748; Med10; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..167
FT /note="Mediator of RNA polymerase II transcription subunit
FT 10"
FT /id="PRO_0000303168"
FT REGION 141..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 167 AA; 18297 MW; 51DD3CCAE59004F7 CRC64;
MAPINPDLQN VQDDIKNVIQ DLFQVLVQVS NYDAAGRPTR DVLAQDIQTL DKTLHTLHTN
AQHLPTPTAD KPIPEPLIQY VENGRNPDIY TREFAELVRR MNQLARGKMH AFRDFRDVLA
REMESALPEL RADVQMVVGA TGGRTVGGEG EGAGQGEGGE GRGEGGN