ID   MED10_COCIM             Reviewed;         163 AA.
AC   Q1E0Q7; J3KCM5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 3.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 10;
DE   AltName: Full=Mediator complex subunit 10;
GN   Name=NUT2; Synonyms=MED10; ORFNames=CIMG_03856;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 10 family.
CC       {ECO:0000305}.
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DR   EMBL; GG704916; EAS32832.3; -; Genomic_DNA.
DR   RefSeq; XP_001244415.2; XM_001244414.2.
DR   AlphaFoldDB; Q1E0Q7; -.
DR   SMR; Q1E0Q7; -.
DR   STRING; 246410.Q1E0Q7; -.
DR   EnsemblFungi; EAS32832; EAS32832; CIMG_03856.
DR   GeneID; 4562685; -.
DR   KEGG; cim:CIMG_03856; -.
DR   VEuPathDB; FungiDB:CIMG_03856; -.
DR   InParanoid; Q1E0Q7; -.
DR   OMA; QYQRAKM; -.
DR   OrthoDB; 1403581at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019145; Mediator_Med10.
DR   Pfam; PF09748; Med10; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..163
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   10"
FT                   /id="PRO_0000303169"
FT   REGION          57..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..78
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   163 AA;  17690 MW;  0B584C799E02E56D CRC64;
     MAPITLSQID EDLKDVIQTF FEIQSAVHGY LGPETQQELV KKLKSLTVSL QTLSAHAAPD
     PSYVQSPPSR TGLSPADPPV QSIQLPPEII DYVDAARNPD IYTREFVELV QKSNQELKGK
     MEAFASFRDV LAKEMASAMP ECKKEVERVV KATGGSVDGG GCG