ID   MED10_PICST             Reviewed;         146 AA.
AC   A3LPQ8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 10;
DE   AltName: Full=Mediator complex subunit 10;
GN   Name=NUT2; Synonyms=MED10; ORFNames=PICST_30038;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 10 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000496; ABN65083.2; -; Genomic_DNA.
DR   RefSeq; XP_001383112.2; XM_001383075.1.
DR   AlphaFoldDB; A3LPQ8; -.
DR   SMR; A3LPQ8; -.
DR   STRING; 4924.XP_001383112.2; -.
DR   EnsemblFungi; ABN65083; ABN65083; PICST_30038.
DR   GeneID; 4836673; -.
DR   KEGG; pic:PICST_30038; -.
DR   eggNOG; KOG3046; Eukaryota.
DR   HOGENOM; CLU_096169_1_0_1; -.
DR   InParanoid; A3LPQ8; -.
DR   OMA; QYQRAKM; -.
DR   OrthoDB; 1403581at2759; -.
DR   Proteomes; UP000002258; Chromosome 2.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019145; Mediator_Med10.
DR   Pfam; PF09748; Med10; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..146
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   10"
FT                   /id="PRO_0000303176"
SQ   SEQUENCE   146 AA;  16324 MW;  461D6C98679774EC CRC64;
     MTTSTIEQKD ENEPLLATAD QVSALIESFI ELGVLVHDNQ GTQQSHTALT HKTNQVISQL
     SGLTSSPFTH QFPIPVDVIS YIEDGRNPDI YTREFIEVTA KSNARLKGKM KAFARLRDVL
     GEKLGNEFPR LVDSIDDIKK RTTPEE