ID   MED10_XENTR             Reviewed;         135 AA.
AC   Q6DJ25;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 10;
DE   AltName: Full=Mediator complex subunit 10;
GN   Name=med10;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 10 family.
CC       {ECO:0000305}.
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DR   EMBL; BC075360; AAH75360.1; -; mRNA.
DR   RefSeq; NP_001004914.1; NM_001004914.1.
DR   AlphaFoldDB; Q6DJ25; -.
DR   SMR; Q6DJ25; -.
DR   STRING; 8364.ENSXETP00000055685; -.
DR   PaxDb; Q6DJ25; -.
DR   DNASU; 448288; -.
DR   Ensembl; ENSXETT00000055685; ENSXETP00000055685; ENSXETG00000026404.
DR   GeneID; 448288; -.
DR   KEGG; xtr:448288; -.
DR   CTD; 84246; -.
DR   Xenbase; XB-GENE-950393; med10.
DR   eggNOG; KOG3046; Eukaryota.
DR   HOGENOM; CLU_096169_3_0_1; -.
DR   InParanoid; Q6DJ25; -.
DR   OMA; YSKHCME; -.
DR   OrthoDB; 1403581at2759; -.
DR   PhylomeDB; Q6DJ25; -.
DR   TreeFam; TF315096; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000026404; Expressed in ovary and 13 other tissues.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0036302; P:atrioventricular canal development; IEA:Ensembl.
DR   GO; GO:1905072; P:cardiac jelly development; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019145; Mediator_Med10.
DR   Pfam; PF09748; Med10; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..135
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   10"
FT                   /id="PRO_0000303157"
SQ   SEQUENCE   135 AA;  15589 MW;  FD2DD7452205ADA4 CRC64;
     MAEKFDNLEE HLEKFVENIR QLGIIVSDFQ PSSQAGLNQK LNFLVTGLQD IDKCRQQLHD
     ITVPLEVFDY IDQGRNPQLY TKECLERALA KNEQVKGKID TLKKFKSLLI QELSKVFPED
     MAKYKAIRGE DHPPS