MED11_ARATH
ID MED11_ARATH Reviewed; 115 AA.
AC Q6ID77;
DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 11;
GN Name=MED11; Synonyms=MED11_1; OrderedLocusNames=At3g01435; ORFNames=T13O15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Shinn P., Chen H., Cheuk R., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT, AND NOMENCLATURE.
RX PubMed=17560376; DOI=10.1016/j.molcel.2007.05.007;
RA Baeckstroem S., Elfving N., Nilsson R., Wingsle G., Bjoerklund S.;
RT "Purification of a plant mediator from Arabidopsis thaliana identifies PFT1
RT as the Med25 subunit.";
RL Mol. Cell 26:717-729(2007).
RN [6]
RP IDENTIFICATION, AND NOMENCLATURE.
RX PubMed=22021418; DOI=10.1104/pp.111.188300;
RA Mathur S., Vyas S., Kapoor S., Tyagi A.K.;
RT "The Mediator complex in plants: structure, phylogeny, and expression
RT profiling of representative genes in a dicot (Arabidopsis) and a monocot
RT (rice) during reproduction and abiotic stress.";
RL Plant Physiol. 157:1609-1627(2011).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. The Mediator complex, having a compact
CC conformation in its free form, is recruited to promoters by direct
CC interactions with regulatory proteins and serves for the assembly of a
CC functional preinitiation complex with RNA polymerase II and the general
CC transcription factors.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000269|PubMed:17560376}.
CC -!- INTERACTION:
CC Q6ID77; Q8RXD6: HUB1; NbExp=2; IntAct=EBI-1386244, EBI-2012188;
CC Q6ID77; Q8LCH5: MED22B; NbExp=3; IntAct=EBI-1386244, EBI-1386287;
CC Q6ID77; F4IXJ7: MED6; NbExp=3; IntAct=EBI-1386244, EBI-1386187;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC {ECO:0000305}.
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DR EMBL; AC010870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002686; AEE73666.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65648.1; -; Genomic_DNA.
DR EMBL; BT014796; AAT41779.1; -; mRNA.
DR EMBL; BT015691; AAU29468.1; -; mRNA.
DR EMBL; AK229334; BAF01197.1; -; mRNA.
DR RefSeq; NP_001327600.1; NM_001337338.1.
DR RefSeq; NP_974205.1; NM_202476.3.
DR AlphaFoldDB; Q6ID77; -.
DR SMR; Q6ID77; -.
DR BioGRID; 30476; 8.
DR IntAct; Q6ID77; 11.
DR STRING; 3702.AT3G01435.1; -.
DR iPTMnet; Q6ID77; -.
DR PaxDb; Q6ID77; -.
DR PRIDE; Q6ID77; -.
DR ProteomicsDB; 239051; -.
DR EnsemblPlants; AT3G01435.1; AT3G01435.1; AT3G01435.
DR EnsemblPlants; AT3G01435.4; AT3G01435.4; AT3G01435.
DR GeneID; 2745869; -.
DR Gramene; AT3G01435.1; AT3G01435.1; AT3G01435.
DR Gramene; AT3G01435.4; AT3G01435.4; AT3G01435.
DR KEGG; ath:AT3G01435; -.
DR Araport; AT3G01435; -.
DR TAIR; locus:1006230250; AT3G01435.
DR eggNOG; ENOG502S141; Eukaryota.
DR HOGENOM; CLU_141299_0_0_1; -.
DR InParanoid; Q6ID77; -.
DR OMA; YVISQLD; -.
DR PhylomeDB; Q6ID77; -.
DR PRO; PR:Q6ID77; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q6ID77; baseline and differential.
DR GO; GO:0016592; C:mediator complex; IDA:UniProtKB.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019404; Mediator_Med11.
DR PANTHER; PTHR22890; PTHR22890; 1.
DR Pfam; PF10280; Med11; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..115
FT /note="Mediator of RNA polymerase II transcription subunit
FT 11"
FT /id="PRO_0000418117"
SQ SEQUENCE 115 AA; 13322 MW; 0A667258161F58C6 CRC64;
MDPQTQNTSL QRLQNVENRV VKVLELAGGV MEELASPSGP KKEFVNSHCR EFMQSMKDIQ
VTLREEIKSA CEYRPFEKCD YNARIANEIC FQKLEYVLTQ LEDLKQTADR YPSSD