ID   MED11_ASHGO             Reviewed;         113 AA.
AC   Q758R2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 11;
DE   AltName: Full=Mediator complex subunit 11;
GN   Name=MED11; OrderedLocusNames=AEL309W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 42-44.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016818; AAS52375.2; -; Genomic_DNA.
DR   RefSeq; NP_984551.2; NM_209904.2.
DR   AlphaFoldDB; Q758R2; -.
DR   SMR; Q758R2; -.
DR   STRING; 33169.AAS52375; -.
DR   EnsemblFungi; AAS52375; AAS52375; AGOS_AEL309W.
DR   GeneID; 4620726; -.
DR   KEGG; ago:AGOS_AEL309W; -.
DR   eggNOG; ENOG502S3YW; Eukaryota.
DR   HOGENOM; CLU_121031_1_0_1; -.
DR   InParanoid; Q758R2; -.
DR   OMA; IMDDNIG; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019404; Mediator_Med11.
DR   Pfam; PF10280; Med11; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..113
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   11"
FT                   /id="PRO_0000304317"
SQ   SEQUENCE   113 AA;  12527 MW;  2657CB92E192C3E2 CRC64;
     MPQPDSVKAR LAALDRIDDE LCAVLQHAQA TIGALAELKR GHAALQPQLE QHVRDYYRTL
     EHSTVALRNE IRELDAAVGT QLLPVNIGKR AVGQDQEKLS EQLAQMDKYV GSM