MED11_CAEEL
ID MED11_CAEEL Reviewed; 188 AA.
AC Q9BI74;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 11;
DE AltName: Full=Mediator complex subunit 11;
GN Name=mdt-11; ORFNames=R144.9;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC {ECO:0000305}.
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DR EMBL; FO080694; CCD65876.1; -; Genomic_DNA.
DR RefSeq; NP_498066.1; NM_065665.3.
DR AlphaFoldDB; Q9BI74; -.
DR SMR; Q9BI74; -.
DR BioGRID; 40915; 29.
DR DIP; DIP-24697N; -.
DR IntAct; Q9BI74; 24.
DR STRING; 6239.R144.9; -.
DR EPD; Q9BI74; -.
DR PaxDb; Q9BI74; -.
DR PeptideAtlas; Q9BI74; -.
DR EnsemblMetazoa; R144.9.1; R144.9.1; WBGene00007015.
DR GeneID; 175682; -.
DR KEGG; cel:CELE_R144.9; -.
DR UCSC; R144.9; c. elegans.
DR CTD; 175682; -.
DR WormBase; R144.9; CE25092; WBGene00007015; mdt-11.
DR eggNOG; KOG4057; Eukaryota.
DR GeneTree; ENSGT00390000010184; -.
DR HOGENOM; CLU_1442300_0_0_1; -.
DR InParanoid; Q9BI74; -.
DR OMA; QIGKNKM; -.
DR OrthoDB; 1526130at2759; -.
DR PhylomeDB; Q9BI74; -.
DR SignaLink; Q9BI74; -.
DR PRO; PR:Q9BI74; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00007015; Expressed in embryo and 4 other tissues.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019404; Mediator_Med11.
DR PANTHER; PTHR22890; PTHR22890; 1.
DR Pfam; PF10280; Med11; 1.
PE 3: Inferred from homology;
KW Activator; Coiled coil; Developmental protein; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..188
FT /note="Mediator of RNA polymerase II transcription subunit
FT 11"
FT /id="PRO_0000304316"
FT REGION 116..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 46..72
FT /evidence="ECO:0000255"
FT COMPBIAS 121..138
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 188 AA; 20339 MW; 8F7A3F970036F31D CRC64;
MEPNPSDPVL TDRIQAIVTT EKSIDEMMKC AREIIQDLGK EKQIGKNKME DNANNFKKLI
TQVENELSAQ MQYLSHVCVG SSHQGSTFGV LQNSLLAQSG LSSLHSELFQ IVRYLDPTSD
EPQTTEEDEE DGSDDLNEDG ADGAPSSTVT SSTTDGSGGG DDAASSSAPR SQEESGRQMT
DDDDDMEQ
