ID   MED11_CANGA             Reviewed;         125 AA.
AC   Q6FN16;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 11;
DE   AltName: Full=Mediator complex subunit 11;
GN   Name=MED11; OrderedLocusNames=CAGL0K03531g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC       {ECO:0000305}.
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DR   EMBL; CR380957; CAG61339.1; -; Genomic_DNA.
DR   RefSeq; XP_448378.1; XM_448378.1.
DR   AlphaFoldDB; Q6FN16; -.
DR   SMR; Q6FN16; -.
DR   STRING; 5478.XP_448378.1; -.
DR   EnsemblFungi; CAG61339; CAG61339; CAGL0K03531g.
DR   GeneID; 2890179; -.
DR   KEGG; cgr:CAGL0K03531g; -.
DR   CGD; CAL0134019; CAGL0K03531g.
DR   VEuPathDB; FungiDB:CAGL0K03531g; -.
DR   eggNOG; ENOG502S3YW; Eukaryota.
DR   HOGENOM; CLU_121031_1_0_1; -.
DR   InParanoid; Q6FN16; -.
DR   OMA; IMDDNIG; -.
DR   Proteomes; UP000002428; Chromosome K.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019404; Mediator_Med11.
DR   Pfam; PF10280; Med11; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..125
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   11"
FT                   /id="PRO_0000304319"
SQ   SEQUENCE   125 AA;  14234 MW;  B3BF3BF8DA05AC38 CRC64;
     MSKSTLEQPE YVKERLESLA EVDRQLCSML QEASQVAFTY GEVLRGNAMM KPQFQEHVSA
     FYSTLDNASG KLKKEIELLD ENVGNRLLPI NVNKKALGQD DDKLKEQMET LKEFLKTDNE
     ETSTS