ID   MED11_DANRE             Reviewed;         114 AA.
AC   A3KNK7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 11;
DE   AltName: Full=Mediator complex subunit 11;
GN   Name=med11;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI33895.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC133894; AAI33895.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001153507.1; NM_001160035.1.
DR   RefSeq; XP_009303543.1; XM_009305268.2.
DR   AlphaFoldDB; A3KNK7; -.
DR   SMR; A3KNK7; -.
DR   STRING; 7955.ENSDARP00000120505; -.
DR   PaxDb; A3KNK7; -.
DR   PeptideAtlas; A3KNK7; -.
DR   GeneID; 100148504; -.
DR   KEGG; dre:100148504; -.
DR   CTD; 400569; -.
DR   ZFIN; ZDB-GENE-091207-2; med11.
DR   eggNOG; KOG4057; Eukaryota.
DR   InParanoid; A3KNK7; -.
DR   OrthoDB; 1581558at2759; -.
DR   PhylomeDB; A3KNK7; -.
DR   TreeFam; TF318328; -.
DR   PRO; PR:A3KNK7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019404; Mediator_Med11.
DR   PANTHER; PTHR22890; PTHR22890; 1.
DR   Pfam; PF10280; Med11; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..114
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   11"
FT                   /id="PRO_0000304310"
FT   COILED          28..61
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   114 AA;  12786 MW;  849149DD1641BECB CRC64;
     MANDRLRALE DVEKEIALVL QSAGTIVLEL SKEKANASLL DRQLNQFQTS INRVESELSS
     QIRYLTQVAT GQPHEGSTYS ARKDCQMALN RAEYARVKLG ELGRTCEMML DPQT