MED11_DEBHA
ID MED11_DEBHA Reviewed; 184 AA.
AC Q6BKI1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 11;
DE AltName: Full=Mediator complex subunit 11;
GN Name=MED11; OrderedLocusNames=DEHA2F21824g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC {ECO:0000305}.
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DR EMBL; CR382138; CAG89691.2; -; Genomic_DNA.
DR RefSeq; XP_461290.2; XM_461290.1.
DR AlphaFoldDB; Q6BKI1; -.
DR SMR; Q6BKI1; -.
DR STRING; 4959.XP_461290.2; -.
DR EnsemblFungi; CAG89691; CAG89691; DEHA2F21824g.
DR GeneID; 2903404; -.
DR KEGG; dha:DEHA2F21824g; -.
DR VEuPathDB; FungiDB:DEHA2F21824g; -.
DR eggNOG; ENOG502S3YW; Eukaryota.
DR HOGENOM; CLU_121031_0_0_1; -.
DR InParanoid; Q6BKI1; -.
DR OMA; IMDDNIG; -.
DR OrthoDB; 1584346at2759; -.
DR Proteomes; UP000000599; Chromosome F.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019404; Mediator_Med11.
DR Pfam; PF10280; Med11; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..184
FT /note="Mediator of RNA polymerase II transcription subunit
FT 11"
FT /id="PRO_0000304320"
FT REGION 142..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 184 AA; 20836 MW; 7BA08D691935ADEF CRC64;
MSIEKESTNN FVQERLDSLY EIDCKIVSLL DNMSSLFQTY STPKSSDNDL TEQKDQMKAQ
TKNIYNAISN VAIGLRKEVK IMDENIGVYN KNKDGIMILP ISVDQKNTTL GTKKLNDEIK
ELNTIVTGEE TDGAMNDTNM EATTKQETNI NNEDSEKEKQ ENITAIETKK ESSENEDEDF
DMIA