ID   MED11_DICDI             Reviewed;         143 AA.
AC   Q54VV8;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Putative mediator of RNA polymerase II transcription subunit 11;
DE   AltName: Full=Putative mediator complex subunit 11;
GN   Name=med11; ORFNames=DDB_G0280109;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18515835; DOI=10.1093/nar/gkn349;
RA   Bourbon H.-M.;
RT   "Comparative genomics supports a deep evolutionary origin for the large,
RT   four-module transcriptional mediator complex.";
RL   Nucleic Acids Res. 36:3993-4008(2008).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000035; EAL67281.1; -; Genomic_DNA.
DR   RefSeq; XP_641247.1; XM_636155.1.
DR   AlphaFoldDB; Q54VV8; -.
DR   STRING; 44689.DDB0266870; -.
DR   PaxDb; Q54VV8; -.
DR   EnsemblProtists; EAL67281; EAL67281; DDB_G0280109.
DR   GeneID; 8622379; -.
DR   KEGG; ddi:DDB_G0280109; -.
DR   dictyBase; DDB_G0280109; med11.
DR   eggNOG; ENOG502RHVU; Eukaryota.
DR   HOGENOM; CLU_1809789_0_0_1; -.
DR   InParanoid; Q54VV8; -.
DR   OMA; PFDHSSY; -.
DR   PRO; PR:Q54VV8; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0070847; C:core mediator complex; ISS:dictyBase.
DR   GO; GO:0001097; F:TFIIH-class transcription factor complex binding; ISS:dictyBase.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:dictyBase.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Developmental protein; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..143
FT                   /note="Putative mediator of RNA polymerase II transcription
FT                   subunit 11"
FT                   /id="PRO_0000388651"
FT   REGION          109..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          97..143
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   143 AA;  16562 MW;  DBD2701D3B736B79 CRC64;
     MNSLSILNNI EDKVVEAINT AALSLESLSA SLDIENTNEN FSKFQTQSDK FYNLVKKDIH
     KGLIDFIDSM TDIAPFDHSS YLKKSELEVS HNFTEIILSH LEDLNNIVEN NQEKQEKEKQ
     EKEKLEKEKL EKEKQQSNEM NID