ID   MED11_XENLA             Reviewed;         118 AA.
AC   Q68EW7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 11;
DE   AltName: Full=Mediator complex subunit 11;
GN   Name=med11;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC       {ECO:0000305}.
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DR   EMBL; BC080083; AAH80083.1; -; mRNA.
DR   RefSeq; NP_001087540.1; NM_001094071.1.
DR   RefSeq; XP_018093354.1; XM_018237865.1.
DR   RefSeq; XP_018093361.1; XM_018237872.1.
DR   AlphaFoldDB; Q68EW7; -.
DR   SMR; Q68EW7; -.
DR   MaxQB; Q68EW7; -.
DR   DNASU; 447364; -.
DR   GeneID; 447364; -.
DR   KEGG; xla:447364; -.
DR   CTD; 447364; -.
DR   Xenbase; XB-GENE-6253996; med11.S.
DR   OMA; IAMVLQC; -.
DR   OrthoDB; 1581558at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 447364; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019404; Mediator_Med11.
DR   PANTHER; PTHR22890; PTHR22890; 1.
DR   Pfam; PF10280; Med11; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..118
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   11"
FT                   /id="PRO_0000304311"
SQ   SEQUENCE   118 AA;  13215 MW;  EE9E1007D510CCE4 CRC64;
     MATFGMANER LRALEEIERE IAAILLNAGN AILELSKEKP NERMLDKQAA QFTASVQRVE
     SELSGQIRYL TQVATGQPHE GSSYSARKDG TMALNRIDYS RVKLAELSRT CEQMLEQP