ID   MED11_XENTR             Reviewed;         118 AA.
AC   Q6P255;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 11;
DE   AltName: Full=Mediator complex subunit 11;
GN   Name=med11;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC       {ECO:0000305}.
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DR   EMBL; BC064722; AAH64722.1; -; mRNA.
DR   RefSeq; NP_989379.1; NM_204048.1.
DR   AlphaFoldDB; Q6P255; -.
DR   SMR; Q6P255; -.
DR   STRING; 8364.ENSXETP00000010935; -.
DR   PaxDb; Q6P255; -.
DR   DNASU; 395010; -.
DR   GeneID; 395010; -.
DR   KEGG; xtr:395010; -.
DR   CTD; 400569; -.
DR   Xenbase; XB-GENE-974069; med11.
DR   eggNOG; KOG4057; Eukaryota.
DR   HOGENOM; CLU_123010_2_0_1; -.
DR   InParanoid; Q6P255; -.
DR   OrthoDB; 1581558at2759; -.
DR   PhylomeDB; Q6P255; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019404; Mediator_Med11.
DR   PANTHER; PTHR22890; PTHR22890; 1.
DR   Pfam; PF10280; Med11; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..118
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   11"
FT                   /id="PRO_0000304312"
SQ   SEQUENCE   118 AA;  13227 MW;  E7896AD7EEDD7A51 CRC64;
     MATYGMANER LRALEEIERE IAAILLNAGN VILELSKEKP NERVLDKQAT QFTASVQRVE
     SELSGQIRYL TQVATGQPHE GSSYSARKDG TMALNRIDYA RVKLAELSRT CDQMLEQP