ID   MED14_ASPCL             Reviewed;        1112 AA.
AC   A1C5W6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE   AltName: Full=Mediator complex subunit 14;
GN   Name=rgr1; Synonyms=med14; ORFNames=ACLA_068140;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC       {ECO:0000305}.
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DR   EMBL; DS027045; EAW13787.1; -; Genomic_DNA.
DR   RefSeq; XP_001275213.1; XM_001275212.1.
DR   AlphaFoldDB; A1C5W6; -.
DR   STRING; 5057.CADACLAP00006593; -.
DR   EnsemblFungi; EAW13787; EAW13787; ACLA_068140.
DR   GeneID; 4708110; -.
DR   KEGG; act:ACLA_068140; -.
DR   VEuPathDB; FungiDB:ACLA_068140; -.
DR   eggNOG; KOG1875; Eukaryota.
DR   HOGENOM; CLU_003573_1_1_1; -.
DR   OMA; FAHAKRA; -.
DR   OrthoDB; 1215335at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR013947; Mediator_Med14.
DR   PANTHER; PTHR12809; PTHR12809; 1.
DR   Pfam; PF08638; Med14; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1112
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   14"
FT                   /id="PRO_0000304592"
FT   REGION          1..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          120..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1088..1112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..141
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1112 AA;  122899 MW;  E4FC5EF6BA11E896 CRC64;
     MPGVVMDNAT VGGPRRASES PDNVSSTPFP QERVNQSGDS GDRRNRSIFH NGAVKGAQGP
     GQHIETHTGK DGINESEGLP ELAHITQGFF PFSTLVNRSV QQCWNDLSEL VTELAAIQVS
     PHGQMPSTPA NGKAPGDQSP ENLQKKTRIL DFAHAKRAEF IKLLVLSQWS RQAGDVSRLI
     DLQNFIRNRH QAFMDALQRI GDMKRDLVQA QVANPDLKTA LEVLSKGRVV SITDLGYEAP
     KQLTAKGALK RLHKINRIIS ARLALHDTIP RPFRTYRVHD GRATFVVQGE FELDLSVGEE
     SKSSQFFFVD IRFLFSPSSH VPKGRLSNEL DVQVNDRLRD NGLKGCFDFL HGLVLTNKIT
     ILFKQAVELA RGLWSDVLRV ELLHRTLVVQ YWALKLGAKS WIEIGIKSGR KPHDVKDSGV
     PYLALRWIRD GQEVDSTSVE FDADDLSMER LLRSIIALHI SHLLSATYSI LNQRSLFATG
     LLSLQALLNT NEPGKCQLLA QLTVSRHLRV SIEPMSGAIV LSADPSPLDR SESDSSLEKS
     SVDDIVSRVS RLRCIAALEE AESTVKILGF ETVSPRGLKA DVRKILPPNI LRFALFWHPF
     WDRSWIVAAT SSTDGDSWWV IHLRRPSALA TSALNLDKDI HREATVCSGH VISNTFLAVQ
     HLARDSSFAD LSHCLSGMVA IHANASYLAD LRSVAFQPPL RALKFESGLE VPNLLVRYQV
     STLPRALQLV FPAGVGKKDF IRNTVRVAFH GIDQRRKVVI FVAYGNLLVP MKELSTLVSK
     LDGSLVFKQE GDSFAIRLLA PAGQPVIVQL FESLQRLECM LSIFEFLRRK KLVIRSLSLS
     QVAFAYGPRR SLAAVMDIGM SKLSNSEQLD PVDILARTDP LLLLRLGIRF DHSNPHRRIQ
     GSLAAILNHT SNKAALDSVA EILSFTLPAM RTLDQITSNL SRGEPARLQV VVRNAFTFLL
     HYINYALRFE LTASQHAGRL TWVLRESGDP QVGPGQDQIR AKLRDTLYNS NGNGWKGLGN
     GVVADVEGVC SVISNLDTSF AGARDNQETS GDVKPTERSL NQTDVKNHRD HDFDAQAAMD
     YDTSAVATNS AGARSSQQCD APPEAADVIT ID